Conditionnement : 500mg
Synonyms:
| Description | Robustaflavone is a naturally occurring biflavonoid isolated from plants such as Nandina domestica and Garcinia latissima. It exhibits potent anti-inflammatory activity by reducing nitric oxide production and suppressing NF-κB activation, while also inducing G0/G1 cell cycle arrest through upregulation of p21 and cleaved caspase 3 in endothelial cells. In osteogenic research, robustaflavone enhances bone regeneration by modulating mitochondrial activity and activating Smad-independent Wnt3a-AKT and MAPK signaling cascades. This compound serves as a valuable scaffold for studying inflammation, angiogenesis, and stem cell-mediated tissue repair. |
| In vitro | Robustaflavone is a biflavanoid that inhibits hepatitis B virus replication in 2.2.15 cells with an EC50 of 0.25 µM and a selectivity index of 153. It shows synergistic anti-HBV activity when combined with penciclovir or lamivudine. |
| In vivo | Robustaflavone demonstrated in vivo anti-angiogenic effects in a CT-26 cell-derived tumor allograft mouse model. Oral administration reduced tumor volumes and weights, and decreased blood vessel density. In a Matrigel plug assay, robustaflavone inhibited VEGF-A-stimulated blood vessel formation. |
| Molecular Weight | 538.46 |
| Formula | C30H18O10 |
| Cas No. | 49620-13-5 |
| Smiles | O=C1C=C(OC=2C=C(O)C=C(O)C12)C=3C=CC(O)=C(C3)C4=C(O)C=C5OC(=CC(=O)C5=C4O)C=6C=CC(O)=CC6 |
| Relative Density. | 1.656g/cm3 |
| Storage | Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
| Size | Quantity | Unit Price | Amount | Operation |
|---|
