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ROCK-IN-1 [934387-35-6]

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Référence NB-64-05001-1mg

Conditionnement : 1mg

Marque : Neo Biotech

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ROCK-IN-1

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Synonyms:

Catalog No. T13419 Copy Product Info

Purity: 99.80%

ROCK-IN-1, a potent ROCK inhibitor, effectively inhibits ROCK2-mediated signaling with an IC₅₀ value of 1.2 nM. ROCK-IN-1 is applicable in the study of neurological disorders and inflammation-related diseases.

Cas No. 934387-35-6

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.80%

Appearance:Solid

Color:Yellow

Product Information

Bioactivity

Description	ROCK-IN-1, a potent ROCK inhibitor, effectively inhibits ROCK2-mediated signaling with an IC₅₀ value of 1.2 nM. ROCK-IN-1 is applicable in the study of neurological disorders and inflammation-related diseases.
Targets & IC50	ROCK2:1.2 nM
In vitro	With an EC₅₀ of 200 nM, ROCK-IN-1 exhibits potent cellular efficacy^[1].

Chemical Properties

Molecular Weight	335.3748
Formula	C₂₀H₁₈FN₃O
Cas No.	934387-35-6
Smiles	CC(N)C1=C(C=C(C=C1)C(=O)NC1=CC=NC=C1)C1=CC=C(F)C=C1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50.00 mg/mL (149.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9817 mL	14.9087 mL	29.8174 mL	149.0869 mL
5 mM	0.5963 mL	2.9817 mL	5.9635 mL	29.8174 mL
10 mM	0.2982 mL	1.4909 mL	2.9817 mL	14.9087 mL
20 mM	0.1491 mL	0.7454 mL	1.4909 mL	7.4543 mL
50 mM	0.0596 mL	0.2982 mL	0.5963 mL	2.9817 mL
100 mM	0.0298 mL	0.1491 mL	0.2982 mL	1.4909 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

ROCK-IN-1ROCKIN1ROCK2ROCK IN 1

Related Tags: ROCK-IN-1 chemical structure | ROCK-IN-1 in vitro | ROCK-IN-1 formula | ROCK-IN-1 molecular weight