Description
A potent, cell-permeable, reversible inhibitor of calpain (IC50= 7.5 nM for calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B(IC50 = 15 nM) and L (IC50 = 1.6 nM). Reduces bFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and -spectrin in cultured lenses.