Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.
 
> SNS 032 [345627-80-7]

SNS 032 [345627-80-7]

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Référence VD-OEIA-1035-5mg

Conditionnement : 5mg

Marque : VDM Biochemicals

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Téléphone : +1 850 650 7790

Product Specification

  • Appearance
    :

    N/A

  • CAS Number
    :

    345627-80-7

  • Cat.number
    :

    VD-OEIA-1035

  • Formula
    :

    C17H24N4O2S2

  • MW
    :

    380.53

  • Purity
    :

    >=99%

  • Solubility
    :

    DMSO

  • Storage
    :

    N/A

  • Synonyms
    :

    BMS 387032; N-(5-(((5-(tert-butyl)oxazol-2-yl)methyl)thio) thiazol-2-yl)piperidine-4-carboxamide

  • Size
    :

    25mg, 5mg

SKU: VD-OEIA-1035 Categories: Enzyme Inhibitors, Other Enzyme Inhibitors and Activators

Description

Specific and potent inhibitor of cyclin-dependent kinases (CDK) 2, 7 and 9 (IC50 values to be 38, 4 and 62 nM for cdk2, cdk7 and cdk9 respectively and no activity against 190 additional kinases); SNS 032 induces cell cycle arrest and apoptosis in tumor cell lines.

1. DS Williamson et al. Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2. Bioorg. Med. Chem. Lett. 2005, 15(4), 863-867.
2. R Chen et al. Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood, 2009, 113(19), 4637-4645.
3. WG Tong et al. Phase I and Pharmacologic Study of SNS-032, a Potent and Selective Cdk2, 7, and 9 Inhibitor, in Patients With Advanced Chronic Lymphocytic Leukemia and Multiple Myeloma. J. Clin. Oncol. 2010, 28(18), 3015-3022.
4. MA Dickson and GK Schwartz. Development of cell-cycle inhibitors for cancer therapy. Curr. Oncol. 2009, 16(2), 36-43.

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