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Sodium 4-phenylbutyrate [1716-12-7]

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Référence NB-64-06605-200mg

Conditionnement : 200mg

Marque : Neo Biotech

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Sodium 4-phenylbutyrate

(Synonyms: TriButyrate, Sodium Phenylbutyrate, Buphenyl) Copy Product Info

Synonyms: TriButyrate, Sodium Phenylbutyrate, Buphenyl

Catalog No. T1535 Copy Product Info

Purity: 99.84%

Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.

Cas No. 1716-12-7

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.84%

Color:White

Product Introduction

Bioactivity

Description	Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.
In vitro	In G93A transgenic ALS mice, Phenylbutyrate improves clinical symptoms and increases survival. It induces the expression of NF-κB p50 in G93A mice, while reducing the expression of cytochrome c and caspases. Additionally, in transgenic mouse models of Huntington's disease (HD), Phenylbutyrate elevates brain protein acetylation levels and reduces histone methylation levels.
In vivo	In prostate cancer cells, Phenylbutyrate induces apoptosis by diminishing the expression levels of the cell apoptosis antagonist Bcl-X(L), the double-strand break repair protein DNA-dependent protein kinase, the prostate progression marker Caveolin-1, and the angiogenesis promoter Vascular Endothelial Growth Factor, thereby weakening their activity.
Synonyms	TriButyrate, Sodium Phenylbutyrate, Buphenyl

Chemical Properties

Molecular Weight	186.183
Formula	C₁₀H₁₁NaO₂
Cas No.	1716-12-7
Smiles	O=C([O-])CCCC1=CC=CC=C1.[Na+]
Relative Density.	1.095g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 33.33 mg/mL (179.02 mM), Sonication is recommended.

DMSO: 33.33 mg/mL (179.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 3.33 mg/mL (17.89 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	5.3711 mL	26.8553 mL	53.7106 mL	268.5530 mL
5 mM	1.0742 mL	5.3711 mL	10.7421 mL	53.7106 mL
10 mM	0.5371 mL	2.6855 mL	5.3711 mL	26.8553 mL
20 mM	0.2686 mL	1.3428 mL	2.6855 mL	13.4276 mL
50 mM	0.1074 mL	0.5371 mL	1.0742 mL	5.3711 mL
100 mM	0.0537 mL	0.2686 mL	0.5371 mL	2.6855 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

TributyrateSodium 4-phenylbutyrateSodium 4phenylbutyrateSodium 4 phenylbutyrateInhibitorinhibitHistone deacetylasesHDACBenzenebutyric acidAutophagyApoptosis4-Phenylbutyric acid4-PBA

Related Tags: Sodium 4-phenylbutyrate chemical structure | Sodium 4-phenylbutyrate in vivo | Sodium 4-phenylbutyrate in vitro | Sodium 4-phenylbutyrate formula | Sodium 4-phenylbutyrate molecular weight