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Tetrahydrocortisol [53-02-1]

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Référence NB-64-08040-50mg

Conditionnement : 50mg

Marque : Neo Biotech

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Tetrahydrocortisol

(Synonyms: Tetrahydrohydrocortisone) Copy Product Info

Synonyms: Tetrahydrohydrocortisone

Catalog No. T17057 Copy Product Info

Purity: 97.01%

Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, and also capable of lowering intraocular pressure.

Cas No. 53-02-1

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.01%

Appearance:Solid

Color:White

Product Information

Bioactivity

Description	Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, and also capable of lowering intraocular pressure.
Targets & IC50	actin network formation (human trabecular meshwork cells):5.7 × 10⁻⁷ M
In vitro	Tetrahydrocortisol dose-dependently inhibited Dexamethasone (10⁻⁷ M)-induced actin network formation in human trabecular meshwork cells (IC₅₀ = 5.7 × 10⁻⁷ M; up to 14 days), and partially reversed microtubule changes, indicating cytoskeletal modulation[1].
Synonyms	Tetrahydrohydrocortisone

Chemical Properties

Molecular Weight	366.49
Formula	C₂₁H₃₄O₅
Cas No.	53-02-1
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)17)([C@@H](O)C1)17)17)(CC[C@@]2(C(CO)=O)O)17
Relative Density.	0.889 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Store at low temperature,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (109.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7286 mL	13.6429 mL	27.2859 mL	136.4294 mL
5 mM	0.5457 mL	2.7286 mL	5.4572 mL	27.2859 mL
10 mM	0.2729 mL	1.3643 mL	2.7286 mL	13.6429 mL
20 mM	0.1364 mL	0.6821 mL	1.3643 mL	6.8215 mL
50 mM	0.0546 mL	0.2729 mL	0.5457 mL	2.7286 mL
100 mM	0.0273 mL	0.1364 mL	0.2729 mL	1.3643 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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