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> TGF alpha Protein, Human, Recombinant

TGF alpha Protein, Human, Recombinant

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Référence NB-64-59020-1mg

Conditionnement : 1mg

Marque : Neo Biotech


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TGF alpha Protein, Human, Recombinant

(Synonyms: transforming growth factor α, transforming growth factor alpha, TGF-α, TGFa, TFGA) Copy Product Info

Synonyms: transforming growth factor α, transforming growth factor alpha, TGF-α, TGFa, TFGA

Catalog No. TMPY-03958 Copy Product Info
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (TGFA) is a well-characterized mammalian growth factor that might contribute to the development of Cleft lip and palate (CL/P).
Other Forms of TGF alpha Protein, Human, Recombinant:
TGF alpha Protein, Human, Recombinant (hFc)
TGF alpha Protein, Mouse, Recombinant (hFc)
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:94.9%
Appearance:Lyophilized powder
Color:White
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Product Information

Bioactivity
Bioactivity
1.Measured by its binding ability in a functional ELISA. Immobilized Human TGF-alpha at 2 μg/ml (100 μl/well) can bind Human EGFR hFc, the EC50 of Human EGFR hFc is 80-500 ng/mL. 2. Measured in a cell proliferation assay using Balb/c 3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.5-2.5 ng/mL.
Description
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (TGFA) is a well-characterized mammalian growth factor that might contribute to the development of Cleft lip and palate (CL/P).
Species
Human
Expression System
E. coli
TagTag Free
Accession NumberP01135-1
ConstructionA DNA sequence encoding the human TGFa (P01135-1) (Val40-Ala89) was expressed and purified. Predicted N terminal: Met
Protein Purity
> 90 % as determined by SDS-PAGE
TGF alpha Protein, Human, Recombinant
EndotoxinPlease contact us for more information.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 100 mM NaCl, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionReconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonymstransforming growth factor α, transforming growth factor alpha, TGF-α, TGFa, TFGA
Research Background
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (TGFA) is a well-characterized mammalian growth factor that might contribute to the development of Cleft lip and palate (CL/P).
Chemical Properties
Molecular Weight5.6 kDa (predicted); 13 kDa (reducing conditions)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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