Specifications

Product Data
Applications	WB
Recommended Dilution	ELISA: 1:1;000. Western blot: 1:1000.
Reactivities	Human
Host	Rabbit
Isotype	Ig
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 160-188 amino acids from the C-terminal region of human UPK1B
Specificity	This antibody detects Uroplakin-1b (UPK1B) (C-term).
Formulation	PBS with 0.09% (W/V) sodium azide State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein A column followed by peptide affinity purification
Conjugation	Unconjugated
Storage	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Gene Name	uroplakin 1B
Database Link	Entrez Gene 7348 Human UniProt ID O75841
Background	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq].
Synonyms	UP1b, Uroplakin Ib, UPIb, Tetraspanin-20, TSPAN20, Tspan-20
Note	Molecular Weight: 29643 Da
Reference Data
Protein Families	Transmembrane