Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie

α-Terpineol [98-55-5]

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Katalog-Nummer NB-64-00115-1mL

Size : 1mLx10mM(inDMSO)

Marke : Neo Biotech

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α-Terpineol

(Synonyms: Terpineol) Copy Product Info

Synonyms: Terpineol

Catalog No. Fr14115 Copy Product Info

Purity: 97.02%

Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.

Cas No. 98-55-5

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.02%

Appearance:solid

Color:White

Product Introduction

α-Terpineol AI Summary

α-Terpineol displays a diverse range of bioactivities across various assays. It functions as a potent modulator of Lamin A splicing with a potency of 3.5 nM and inhibits Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) with a potency of 89125.1 nM. Additionally, it inhibits the binding or entry of Marburg Virus into cells with a potency of 2238.7 nM. In anti-asthmatic applications, α-Terpineol reduces acetylcholine-induced muscle contractions and promotes muscle relaxation in guinea pig tracheal smooth muscle rings. It improves lung function in ovalbumin-induced asthmatic Sprague-Dawley rats by decreasing serum IL-17 and IL-14 levels and enhancing airway compliance. Moreover, it acts as an agonist at the beta-adrenergic receptor in rat airway smooth muscle cells, increasing cAMP levels post-acetylcholine stimulation. In neurological studies, α-Terpineol serves as a positive allosteric modulator of the recombinant human GABAA alpha1beta2gamma2s receptor, achieving a GABA-stimulated current amplitude of 91.2% of the control in Xenopus laevis oocytes. It has a sedative effect in Swiss mice, reducing motility by 45.0% at a concentration of 34 nM. Antimicrobial activities were observed against Candida albicans (MIC of 0.125% v/v), Gardnerella vaginalis (MIC of 0.06% v/v), and Escherichia coli CMCC 44102 (MIC of 0.78 uL/ml). Additionally, it inhibits ARAT and LRAT enzymes in bovine RPE microsomes, with inhibition rates of 26.0% and 25.0% respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.
Synonyms	Terpineol

Chemical Properties

Molecular Weight	154.25
Formula	C₁₀H₁₈O
Cas No.	98-55-5
Smiles	C(C)(C)(O)C1CCC(C)=CC1
Relative Density.	0.93 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (291.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (32.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4830 mL	32.4149 mL	64.8298 mL	324.1491 mL
5 mM	1.2966 mL	6.4830 mL	12.9660 mL	64.8298 mL
10 mM	0.6483 mL	3.2415 mL	6.4830 mL	32.4149 mL
20 mM	0.3241 mL	1.6207 mL	3.2415 mL	16.2075 mL
50 mM	0.1297 mL	0.6483 mL	1.2966 mL	6.4830 mL
100 mM	0.0648 mL	0.3241 mL	0.6483 mL	3.2415 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

α-TerpineolαTerpineolα TerpineolInhibitorinhibitILReceptorIL ReceptorBacteriala-TerpineolAnti-infectionAntiinfectionAntifectionalpha-Terpineol

Related Tags: α-Terpineol chemical structure | α-Terpineol formula | α-Terpineol molecular weight