Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie

2-D08 [144707-18-6]

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Katalog-Nummer NB-64-41432-5mg

Size : 5mg

Marke : Neo Biotech

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2-D08

Catalog No. T7379 Copy Product Info

Purity: 98.95%

2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.

2-D08

Copy Product Info

2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.

Cas No. 144707-18-6

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Batch Information

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Purity:98.95%

Color:Yellow

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
Targets&IC50	Axl:0.49 nM
In vitro	2-D08 inhibits sumoylation of topoisomerase I in the breast cancer cell lines ZR-75-1 and BT-474.[1] It specifically disrupts the transfer of SUMO from the E2 enzyme (UBC9) thioester conjugate to the substrate. 2-D08 prevents amyloid-β (Aβ) (1-42) aggregation and Aβ-induced toxicity in PC12 cells. It also has antioxidant properties[2].

Chemical Properties

Molecular Weight	270.24
Formula	C₁₅H₁₀O₅
Cas No.	144707-18-6
Smiles	Oc1ccc(c(O)c1O)-c1cc(=O)c2ccccc2o1
Relative Density.	1.548 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 123.75 mg/mL (457.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (18.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7004 mL	18.5021 mL	37.0041 mL	185.0207 mL
5 mM	0.7401 mL	3.7004 mL	7.4008 mL	37.0041 mL
10 mM	0.3700 mL	1.8502 mL	3.7004 mL	18.5021 mL
20 mM	0.1850 mL	0.9251 mL	1.8502 mL	9.2510 mL
50 mM	0.0740 mL	0.3700 mL	0.7401 mL	3.7004 mL
100 mM	0.0370 mL	0.1850 mL	0.3700 mL	1.8502 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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