Acalabrutinib
Katalog-Nummer orb1303984-5mg
Size : 5mg
Marke : Biorbyt
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Telefonnummer : +1 850 650 7790
| Catalog Number | orb1303984 |
|---|---|
| Category | Small Molecules |
| Description | Acalabrutinib |
| CAS Number | 1420477-60-6 |
| Purity | 99.95% |
| MW | 465.51 |
| SMILES | C(C#CC)(=O)N1[C@H](C=2N3C(=C(N2)C4=CC=C(C(NC5=CC=CC=N5)=O)C=C4)C(N)=NC=C3)CCC1 |
| Formula | C26H23N7O2 |
| Biological Activity | Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival. |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |