AH-7614 [6326-06-3]
Katalog-Nummer T22027-10mg
Size : 10mg
Marke : TargetMol
AH-7614
(Synonyms: AH 7614) Copy Product Info
AH-7614 (AH 7614) is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.
Cas No. 6326-06-3
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.05%
Appearance:Solid
Color:White
COA LCMS HNMR
Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AH-7614 (AH 7614) is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist. |
| In vitro | AH7614 (0.063, 0.25, and 1μM) blocked linoleic acid and GSK137647A-induced intracellular calcium increase in U2OS osteosarcoma cells expressing the FFA4 receptor. In addition, the increase of glucose-stimulated insulin secretion by GSK137647A (50 μM) was abolished in the presence of the selective FFA4 antagonist AH7614 (100 μM) in the MIN6 mouse insulinoma cell line. Moreover, AH7614 (100 μM) blocked GSK137647A (100μM)-mediated a modest increase of GLP-1 secretion in the NCIH716 cells. |
| Synonyms | AH 7614 |
| Molecular Weight | 351.42 |
| Formula | C20H17NO3S |
| Cas No. | 6326-06-3 |
| Smiles | Cc1ccc(cc1)S(=O)(=O)NC1c2ccccc2Oc2ccccc12 |
| Relative Density. | 1.37 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (355.7 mM), Sonication is recommended.  Ethanol: Insoluble H2O: Insoluble | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 2.5 mg/mL (7.11 mM), Sonication is recommended. 10% DMSO+90% Saline: < 10 mg/mL (28.46 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (28.46 mM), Solution. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||