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Anti-PLGF Polyclonal Antibody

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Katalog-Nummer NB-64-161477-100uL

Size : 100uL

Marke : Neo Biotech


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Anti-PLGF Polyclonal Antibody

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Synonyms:

Catalog No. TMAB-11551 Copy Product Info
Anti-PLGF Polyclonal Antibody is a Rabbit antibody targeting PLGF. Anti-PLGF Polyclonal Antibody can be used in WB.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Description
Anti-PLGF Polyclonal Antibody is a Rabbit antibody targeting PLGF. Anti-PLGF Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Rat (predicted:Mouse,Pig)
Verified Activity
Sample: Placenta (Rat) Lysate at 30 μg
Primary: rabbit Anti-PLGF (TMAB-11551) at 1:300 dilution;
Secondary: HRP conjugated Goat-Anti-rabbit IgG at 1: 5000 dilution;
Predicted band size:16 kD
Observed band size:16 kD
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationSecreted. The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
Tissue SpecificityWhile the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThe placental-derived growth factor (PIGF) is a dimeric glycoprotein showing a high degree of sequence similarity to the vascular endothelial growth factor. Alternative splicing of the PIGF primary transcript gives rise to two forms, named PIGF-1 and PIGF-2, which differ only in the insertion of a highly basic 21-amino acid stretch at the carboxyl end. The presence of the PIGF mRNA in thyroid, placenta, lung, and goiter has indicated the tissues where this factor functions. However, the role of PIGF in vascular development has not yet been clearly established.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: mouse PLGF
Antigen Species
Mouse
Gene Name
PGF
Gene ID
18654
Protein Name
Placenta growth factor
Uniprot ID
P49764
Function
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
Chemical Properties
Molecular WeightTheoretical: 16 kDa. Actual: 16 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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