Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie

Anti-Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503) Antibody

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Katalog-Nummer p1550-503t

Size : 25uL

Marke : Phosphosolutions

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Anti-Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503) Antibody

Our Anti-Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects hamster, mouse and rat Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503) and is antigen affinity purified from pooled serum. It is great for use in WB, IHC, ICC.

Immunostaining of Chinese Hamster Overy (CHO) cells stably transfected with KV3.1b gene with the phospho-Ser503 Kv3.1 subunit antibody (Cat. p1550-503, green, 1:400). The image on the right shows cells that have been treated with the protein kinase C activator PMA (500nM) while the control cells are on the left.

Click on image to zoom

Species Reactivity

Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Rabbit

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Data Sheet

Trial Size

Pooled Serum

SKU: p1550-503

Ships: 1-2 business days

Product Details

Target

Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503)

Scientific Background

Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

Format

Antigen Affinity Purified from Pooled Serum

Clonality

Polyclonal

Isotype

IgG

Applications

ICC, IHC, WB

Host Species

Rabbit

Gene Name

KCNC1

Molecular Weight

100 kDa

Immunogen

The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser503 of the rat voltage-gated potassium channel Kv3.1, conjugated to keyhole limpet hemocyanin (KLH).

Immunogen Species

Rat

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2492212

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
IHC: 1:400-1:1000
ICC: 1:400

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~100 kDa Kv3.1 voltage-gated potassium channel protein phosphorylated at Ser503.

Post Translational Modification Type

Phosphorylated

Post Translational Modification Residue

Ser503

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

C230009H10Rik antibody, FLJ41162 antibody, FLJ42249 antibody, FLJ43491 antibody, Kcnc1 antibody, KCNC1 antibody, KCNC1_HUMAN antibody, Kcr2 1 antibody, KShIIIB antibody, Kv3.1 antibody, Kv4 antibody, MGC129855 antibody, NGK2 antibody, Potassium voltage-gated channel subfamily C member 1 antibody, Shaw antibody, Voltage gated potassium channel antibody, Voltage gated potassium channel subunit Kv3.1 antibody, Voltage-gated potassium channel subunit Kv3.1 antibody, Voltage-gated potassium channel subunit Kv4 antibody

UniProt ID

P25122

NCBI Gene ID

25327

Shipping

Blue Ice

Potassium Channel, Voltage-Gated, Kv3.1 Subunit Ser503 ICC Protocol: Download

Western Blot Protocol: Download

Anti-Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503) Antibody

Katalog-Nummer p1550-503t

Marke : Phosphosolutions

Anti-Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503) Antibody

SKU: p1550-503

Product Details

Bulk Order Anti-Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503) Antibody