General Info
Host: | Rabbit |
Applications: | CM/ELISA/ICC/IF/IHC/WB |
Reactivity: | Horse/Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-RAPGEF3 (526-541) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Biotin |
Isotype: | IgG |
Purification: | Affinity Purified |
Concentration: | 0.59 µg/µl |
Dilution Range: | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IHC: 1:200ICC: 1:200IF: 1:200CFM: 1:200 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
Gene Symbol: | RAPGEF3 |
Gene ID: | 10411 |
Uniprot ID: | RPGF3_HUMAN |
Immunogen Region: | 526-541 |
Specificity: | Does not cross react with Epac2. |
Immunogen: | Synthetic peptide corresponding to amino acids 526-541 of Epac1 protein, peptide was covalently modified. Sequence DHSVLTLQLQLPVTASVR |
Description
Tissue Specificity | Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. |
Function | Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin. |
Protein Name | Rap Guanine Nucleotide Exchange Factor 3Exchange Factor Directly Activated By Camp 1Exchange Protein Directly Activated By Camp 1Epac 1Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By CampCamp-Regulated Guanine Nucleotide Exchange Factor ICamp-Gefi |
Database Links | Reactome: R-HSA-354192Reactome: R-HSA-381676Reactome: R-HSA-392517Reactome: R-HSA-422356 |
Cellular Localisation | Endomembrane System |
Alternative Antibody Names | Anti-Rap Guanine Nucleotide Exchange Factor 3 antibodyAnti-Exchange Factor Directly Activated By Camp 1 antibodyAnti-Exchange Protein Directly Activated By Camp 1 antibodyAnti-Epac 1 antibodyAnti-Rap1 Guanine-Nucleotide-Exchange Factor Directly Activated By Camp antibodyAnti-Camp-Regulated Guanine Nucleotide Exchange Factor I antibodyAnti-Camp-Gefi antibodyAnti-RAPGEF3 antibodyAnti-CGEF1 antibodyAnti-EPAC antibodyAnti-EPAC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance