AQP9 Antibody
Katalog-Nummer OABF00907
Size : 100ul
Marke : Aviva Systems Biology
EGFR Recombinant Antibody [9F10] (OACA12311)
| Datasheets/Manuals | Printable datasheet for EGFR Recombinant Antibody [9F10] (OACA12311) |
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| Predicted Species Reactivity | Human |
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| Product Format | Liquid |
| Clonality | Recombinant Monoclonal |
| Conjugation | Unconjugated |
| Application | Enzyme-linked immunosorbent assay, Flow cytometry, Immunofluorescence, Immunohistochemistry, Western blot |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | A synthesized peptide derived from human EGFR (ErbB 1) |
| Purification | Affinity Purified |
| Gene Symbol | EGFR |
|---|---|
| Gene Full Name | epidermal growth factor receptor |
| Alias Symbols | avian erythroblastic leukemia viral (v-erb-b) oncogene homolog;cell growth inhibiting protein 40;cell proliferation-inducing protein 61;epidermal growth factor receptor;epidermal growth factor receptor tyrosine kinase domain;ERBB;ERBB1;erb-b2 receptor tyrosine kinase 1;ERRP;HER1;mENA;NISBD2;PIG61;proto-oncogene c-ErbB-1;receptor tyrosine-protein kinase erbB-1. |
| NCBI Gene Id | 1956 |
| Protein Name | Epidermal growth factor receptor |
| Description of Target | Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Plays a role in enhancing learning and memory performance (By similarity). |
| Uniprot ID | P00533 |