Specifications

Product Data
Applications	IHC, WB
Recommended Dilution	WB: 200-1000 WB positive control: K562, 293T cells and hepG2 IHC: 50-200 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm, Nucleus
Reactivities	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1460-1474 amino acids of Human SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member?
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage	Store at -20°C as received.
Stability	Stable for 12 months from date of receipt.
Predicted Protein Size	185 kDa
Gene Name	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Database Link	NP_003063 Entrez Gene 20586 MouseEntrez Gene 171379 RatEntrez Gene 6597 Human UniProt ID P51532
Background	The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI; which is required for transcriptional activation of genes normally repressed by chromatin. In addition; this protein can bind BRCA1; as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms	BAF190; BAF190A; BRG1; CSS4; hSNF2b; MRD16; RTPS2; SNF2; SNF2L4; SNF2LB; SWI2
Reference Data
Protein Families	Druggable Genome, Transcription Factors