CD14 Mouse Monoclonal Antibody [Clone ID: Tük4]
Katalog-Nummer SM1066RT
Size : 25Tests
CD14 Mouse Monoclonal Antibody [Clone ID: Tük4]
SKU
SM1066RT
CD14 mouse monoclonal antibody, clone Tük4, PE
| Product Data | |
| Clone Name | Tük4 |
|---|---|
| Application | FC |
| Recommended Dilution | Flow Cytometry: Use 10 µl of Neat-1/10 diluted antibody to label 106 cells or 100 µl whole blood. |
| Reactivity | Bovine, Canine, Feline, Goat, Human, Mink, Monkey, Porcine, Rabbit, Sheep |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | CD14 Human |
| Specificity | This antibody recognises the CD14 cell surface antigen, expressed strongly by most peripheral blood monocytes and weakly on granulocytes. Clone TÜK4 has been shown to block SDF-induced chemotaxis of U937 cells in a dose-dependent manner. The use of SM1066LE is recommended for this purpose. |
| Buffer | PBS Label: PE State: Lyophilized purified IgG fraction Stabilizer: 1% BSA, 5% Sucrose Preservative: 0.09% Sodium Azide Label: R. Phycoerythrin |
| Reconstitution Method | Restore with 1 ml distilled water |
| Purification | Affinity Chromatography on Protein G |
| Conjugation | PE |
| Storage | Prior to and following reconstitution store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | CD14 molecule |
| Database Link | |
| Background | CD14 is a single copy gene encoding 2 protein forms: a 50 to 55 kDa glycosylphosphatidylinositol anchored membrane protein (mCD14) and a monocyte or liver derived soluble serum protein (sCD14) that lacks the anchor. Both molecules are critical for lipopolysaccharide (LPS) dependent signal transduction, and sCD14 confers LPS sensitivity to cells lacking mCD14. Increased sCD14 levels are associated with inflammatory infectious diseases and high mortality in gram negative shock. CD14 also appears to be involved in clearance of gram-negative bacteria via its high affinity binding to LPS-LPB complexes. |
| Synonyms | CD14 |
| Reference Data | |
| Protein Categories | Allergies and autoimmune diseases, CD Markers, Cytokines, Secreated Proteins |
| Product Manuals |
| FAQs |
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| SDS |
| Antibody Resources |
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Citations
The effect of colostrum ingestion during the first 24 hours of life on early postnatal development of piglet immune systems
Ogawa, Tsukahara, Imaoka et al
Anim Sci J (2016) 87 (12), 1511-1515 DOI: 10.1111/asj.12573
Ogawa, Tsukahara, Imaoka et al
Anim Sci J (2016) 87 (12), 1511-1515 DOI: 10.1111/asj.12573
Cited by 34
AI Summary: OriGene products contributed to this study by providing the anti-pig CD19 antibody (Cat# SM1956P) used for flow cytometric analysis of blood B cell populations in piglets.
RNA of Enterococcus faecalis Strain EC-12 Is a Major Component Inducing Interleukin-12 Production from Human Monocytic Cells
Nishibayashi, Inoue, Harada et al
PLoS One (2015) 10 (6), e0129806 DOI: 10.1371/journal.pone.0129806
Nishibayashi, Inoue, Harada et al
PLoS One (2015) 10 (6), e0129806 DOI: 10.1371/journal.pone.0129806
Cited by 25
AI Summary: OriGene products contributed to this study by providing siRNAs targeting TLR7 and TLR8 (OriGene, SR307236 for TLR7 and SR320236 for TLR8), which were used to demonstrate that TLR8, but not TLR7, mediates the recognition of E. faecalis EC-12 RNA and subsequent IL-12 production in human monocytic cells.
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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