AR50367PU-S | CD274 / PDL1 (19-238, His-Tag) Human Protein Clinisciences

CD274 / PDL1 (19-238, His-Tag) Human Protein

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AR50367PU-S

Recombinant human PD-L1/B7-H1 protein (CD274)

Specifications
Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence FTVTV PKDLYVVEYG SNMTIECKFP VEKQLDLAAL IVYWEMEDKN IIQFVHGEED LKVQHSSYRQ RARLLKDQLS LGNAALQITD VKLQDAGVYR CMISYGGADY KRITVKVNAP YNKINQRILV VDPVTSEHEL TCQAEGYPKA EVIWTSSDHQ VLSGKTTTTN SKREEKLFNV TSTLRINTTT NEIFYCTFRR LDPEENHTAE LVIPELPLAH PPNER
Tag	His-Tag
Predicted MW	27.9 kDa (245aa) confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
Concentration	1mg/ml (determined by Bradford assay)
Purity	> 90% by SDS-PAGE
Presentation State	Purified
Buffer	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 1mM DTT
Preparation	Liquid purified protein
Recommended Dilution	SDS-PAGE
Protein Description	Recombinant Human CD274 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Storage	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability	Shelf life: one year from despatch.
Shipping	Blue Ice
Reference Data
RefSeq	NP_054862
Locus ID	29126
UniProt ID	Q9NZQ7
Cytogenetics	9p24.1
Synonyms	Programmed cell death 1 ligand, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1
Summary	This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. provided by RefSeq, Sep 2015
Protein Categories	ADC Targets, CAR-T Targets, CD Markers, Cytokines, Membrane Proteins
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs)

FAQs
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SDS
SDS for AR50367PU-S

Recombinant Protein Resources
Video tutorial: Why protein expression host matters Webinar Video: Overexpression lysate as positive controls for Western blot Product Overview Video: Overexpression lysates as positive controls for Western blot Video Tutorial: Knockout(KO) lysate and antibody specificity Product Brochure: Protein

Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

CD274 / PDL1 (19-238, His-Tag) Human Protein

Katalog-Nummer AR50367PU-S

CD274 / PDL1 (19-238, His-Tag) Human Protein

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