DRD4 Human Recombinant Protein, Synthetic Nanodisc
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SKU
TP728691M
Recombinant Human DRD4 full length protein-Synthetic Nanodisc, 100 ug
Specifications
Product Data
Species
Human
Expression Host
HEK293
Tag
C-Flag & Strep Tag
Predicted MW
43.9 kDa
Concentration
Please refer to the Certificate of Analysis (COA) for the lot-specific concentration before lyophilization.
Buffer
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with pH lower than 6.5 in subsequent experiments.
Reconstitution Method
1. Before opening the tube cap, centrifuge the sample tube at 5000g for 3-5min at room temperature to ensure the lyophilized sample settles down at the bottom of the tube. 2. Calculate the volume for reconstitution (in µL) using the formula: Quantity (mg)/Concentration (mg/mL)x1000 3. Dissolve the lyophilized protein sample in sterile water based on the calculated volume (µL) 4. After adding sterile water, cover the lid and mix by gently tapping the tube 5-10 times. Note: Do not vortex or vigorously pipette the sample.
Storage
Store at -20°C to -80°C for 12 months in lyophilized form.
Stability
After reconstitution, if not intended for use within a month, aliquot and store at -80°C . Avoid repeated freezing and thawing.
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. provided by RefSeq, Jul 2008
Protein Categories
GPCR, Membrane Proteins
Protein Families
Druggable Genome, GPCR, Transmembrane
Protein Pathways
GPCRDB Class A Rhodopsin-like, GPCRDB Other, Monoamine GPCRs
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
