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EGFR Protein, Rat, Recombinant (His)

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Katalog-Nummer NB-64-58050-10ug

Size : 10ug

Marke : Neo Biotech


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EGFR Protein, Rat, Recombinant (His)

(Synonyms: epidermal growth factor receptor) Copy Product Info

Synonyms: epidermal growth factor receptor

Catalog No. TMPY-02958 Copy Product Info
EGFR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is E7CXR8.
Other Forms of EGFR Protein, Rat, Recombinant (His):
EGFR vIII Protein, Human, Recombinant (hFc)
EGFR vIII Protein, Human, Recombinant (His)
EGFR Protein, Human, Recombinant (His & Avi), FITC-Labeled
EGFR Protein, Human, Recombinant (His & Avi)
EGFR Protein, Human, Recombinant (His & Avi), Biotinylated
EGFR Protein, Rhesus macaque, Recombinant (His)
EGFR Protein, Rhesus, Recombinant (hFc)
EGFR Protein, Human, Recombinant (His)
EGFR Protein, Human, Recombinant (hFc)
EGFR Protein, Mouse, Recombinant (hFc)
EGFR Protein, Mouse, Recombinant (His)
EGFR Protein, Canine, Recombinant (His)
EGFR Protein, Human, Recombinant (aa 668-1210, His & GST)
EGFR Protein, Cynomolgus, Recombinant (His)
EGFR Protein, Human, Recombinant (Isoform vIII, aa 1-375, His)
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Bioactivity
1. Measured by its ability to bind recombinant human EGF-Fc in a functional ELISA. 2. Measured by its ability to bind recombinant mouse EGF-Fc in a functional ELISA.
Description
EGFR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.7 kDa and the accession number is E7CXR8.
Species
Rat
Expression System
HEK293 Cells
TagC-His
Accession NumberE7CXR8
ConstructionA DNA sequence encoding the rat EGFR (E7CXR8) (Met1-Ser646) was expressed, fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Leu 25
Protein Purity
≥ 98 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonymsepidermal growth factor receptor
Research Background
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Chemical Properties
Molecular Weight70.7 kDa (predicted); 93-110 kDa (reducing condition, due to glycosylation)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Related Tags: EGFR Protein, Rat, Recombinant (His) chemical structure | EGFR Protein, Rat, Recombinant (His) molecular weight