Size : 500mg
Synonyms:
| Description | Fucoidan is found in various species of brown seaweed and algae,with anticancer, antiviral, neuroprotective, immune-modulating. |
| In vitro | Fucoidan significantly decreased viable cell number in a dose-response manner with an IC50 of 550 ±4.3 μg/mL.?Cell morphology was altered and significant apoptosis was induced when cells were exposed to 550 μg/mL fucoidan for 48 h[1]. |
| In vivo | Intraperitoneal injection of fucoidan in breast cancer models reduced the tumor volume and weight.?The enhanced antitumor efficacy was associated with decreased angiogenesis and increased induction of apoptosis[2]. |
| Cell Research | The influence of fucoidan on B16 melanoma cells and cellular tyrosinase:Cell viability was examined by the cell counting kit-8 assay. Cellular tyrosinase activity and melanin content were determined using spectrophotometric methods and protein expression was analyzed by immunoblotting. Morphological changes in B16 melanoma cells were examined by phase contrast microscopy and apoptosis was analyzed by flow cytometry[1]. |
| Animal Research | In vivo, therapy experiments were conducted on Babl/c mice bearing breast cancer.?The tumor volume and weight were measured.?The number of apoptotic cells and microvascular density (MVD) in tumor tissues were assessed by TUNEL and CD34 immunostaining.?Immunohistochemical assays and ELISA assay were used to detect the expression of VEGF in tissues[2]. |
| Molecular Weight | 256.27 |
| Formula | C8H16O7S |
| Cas No. | 9072-19-9 |
| Smiles | CO[C@@H]1[C@@H](C)O[C@@H](C)[C@@H](OS(O)(=O)=O)[C@H]1O |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | H2O: 10 mM, Sonication is recommended. DMSO: Insoluble | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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