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> Fullerene-C60 [99685-96-8]

Fullerene-C60 [99685-96-8]

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Katalog-Nummer T41141-100mg

Size : 100mg

Marke : TargetMol


Fullerene-C60

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Fullerene-C60 is a potent free radical scavenger with a wide range of bioactivities that can attenuate liver injury and hepatotoxicity, and improve intestinal flora structure and lipid homeostasis.
Fullerene-C60
Cas No. 99685-96-8
For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid
Color:Black

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Product Information

Bioactivity
Description
Fullerene-C60 is a potent free radical scavenger with a wide range of bioactivities that can attenuate liver injury and hepatotoxicity, and improve intestinal flora structure and lipid homeostasis.
In vitro
Methods: To estimate the accumulation of Fullerene-C60 in leukemic cells and to investigate its phototoxic effects on parental and cisplatin-treated leukemic cells. A stable homogeneous hydrocolloid solution of pristine C60 with an average nanoparticle diameter of 50 nm was used in the experiments. Fluorescently labeled C60 was synthesized by covalently coupling C60 with rhodamine B isothiocyanate.
Results: Confocal microscopy Results showed that leukemic Jurkat cells could efficiently take up Fullerene-C60 from the culture medium. Light-emitting diode light (100 mW cm-2, λ = 420–700 nm) was used to excite the accumulated C60. When leukemic Jurkat cells were exposed to a combination of C60 and visible light treatment, a time-dependent decrease in viability was detected. [1]
Chemical Properties
Molecular Weight720.64
FormulaC60
Cas No.99685-96-8
SmilesC=12C3=C4C=5C1C6=C7C=8C2=C9C%10=C3C=%11C%12=C4C%13=C%14C5C%15=C6C%16=C7C%17=C%18C8C9=C%19C%20=C%10C%11C%21=C%22C%12=C%13C%23=C%24C%14=C%15C%25=C%16C%26=C%17C=%27C%18=C%19C=%28C%20=C%21C=%29C%22=C%23C%30=C%24C%25=C%26C=%31C%27C%28C%29C%30%31
Storage & Solubility Information
StorageKeep away from direct sunlight,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: < 1 mg/mL, insoluble
H2O: < 1 mg/mL, insoluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 µL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

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