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GPCR agonist-2 [291528-35-3]

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Katalog-Nummer NB-64-30532-25mg

Size : 25mg

Marke : Neo Biotech

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GPCR agonist-2

(Synonyms: 4-(Cyclopropylamino)-3-nitrobenzoic acid) Copy Product Info

Synonyms: 4-(Cyclopropylamino)-3-nitrobenzoic acid

Catalog No. T60074 Copy Product Info

Purity: 99.96%

GPCR agonist-2 (4-(Cyclopropylamino)-3-nitrobenzoic acid) is an agonist of the orphan human GPCR GPR109B.

Cas No. 291528-35-3

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.96%

Appearance:Solid

Color:Yellow

Product Introduction

GPCR agonist-2 AI Summary

GPCR agonist-2 exhibits agonist activity at the human GPR109b receptor when transfected in CHOK1 cells. Its bioactivity is demonstrated by the reversal of forskolin-induced cAMP elevation in a whole cell assay, with an EC50 value of 309.03 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	GPCR agonist-2 (4-(Cyclopropylamino)-3-nitrobenzoic acid) is an agonist of the orphan human GPCR GPR109B.
Synonyms	4-(Cyclopropylamino)-3-nitrobenzoic acid

Chemical Properties

Molecular Weight	222.2
Formula	C₁₀H₁₀N₂O₄
Cas No.	291528-35-3
Smiles	N(=O)(=O)C1=C(NC2CC2)C=CC(C(O)=O)=C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (225.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5005 mL	22.5023 mL	45.0045 mL	225.0225 mL
5 mM	0.9001 mL	4.5005 mL	9.0009 mL	45.0045 mL
10 mM	0.4500 mL	2.2502 mL	4.5005 mL	22.5023 mL
20 mM	0.2250 mL	1.1251 mL	2.2502 mL	11.2511 mL
50 mM	0.0900 mL	0.4500 mL	0.9001 mL	4.5005 mL
100 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2502 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

WAY622024WAY 622024GPR109BGPCR agonist-2

Related Tags: GPCR agonist-2 chemical structure | GPCR agonist-2 formula | GPCR agonist-2 molecular weight