Human CBL Antibody : APC (Phospho-Tyr774)
Katalog-Nummer OAAQ00187-100tests
Size : 100Tests
Marke : Aviva Systems Biology
Human CBL Antibody : APC (Phospho-Tyr774)
Human CBL Antibody : APC (Phospho-Tyr774) (OAAQ00187)
| Datasheets/Manuals | Printable datasheet for OAAQ00187 |
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| Tested Species Reactivity | Human, Mouse |
|---|---|
| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA. |
| Clonality | Monoclonal |
| Clone | CblY774-R3B8 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | APC: Allophycocyanin |
| Application | FC |
| Reconstitution and Storage | 2-8C |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr774 of human phospho c-Cbl |
| Purification | Protein A+G |
| Target Post-Translational Modification | Phospho-Tyr774 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | 1. Christine, B.F. et al. (2001) Nat. Rev. Mol. Cell Biol. 2: 294-307. 2. Feshchenko, E.A. et al. (1998) J. Biol. Chem. 273: 8323-8331. 3. Blake, T.J. et al. (1991) Oncogene. 6: 653-657. 4. Thien, C.B. and Langdon, W.Y. (1998) Immunol. Cell Biol. 76: 473-482. 5. Kamei, T. et al. (2000) Int. J. Oncol. 17: 335-339. |
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| Gene Symbol | CBL |
| Gene Full Name | Cbl proto-oncogene |
| Alias Symbols | CBL2, NSLL, C-CBL, RNF55, FRA11B |
| NCBI Gene Id | 867 |
| Protein Name | E3 ubiquitin-protein ligase CBL |
| Description of Target | This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. |
| Uniprot ID | P22681 |
| Protein Accession # | NP_005179.2 |
| Nucleotide Accession # | NM_005188.3 |
