Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie

Ivosidenib [1448347-49-6]

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Katalog-Nummer T3617-25mg

Size : 25mg

Marke : TargetMol

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Ivosidenib

(Synonyms: AG-120) Copy Product Info

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Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.

Cas No. 1448347-49-6

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:99.98%

ee:99.97%

Color:White

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COA HNMR CSFC LCMS

Product Information

Bioactivity

Description	Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.
Targets & IC50	IDH1 (R132H):12 nM
In vitro	TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120.Treatment with AG-120 decreases intracellular 2-HG levels, inhibites growth factor independent proliferation and restores erythropoietin (EPO)-induced differentiation in TF-1 IDH1-R132H cells. Similarly, pharmacological inhibition of mutant IDH1 enzyme with AG-120 in primary human blast cells cultured ex vivo provides an effective way to lower intracellular 2-HG levels and induces myeloid differentiation^[1].
Synonyms	AG-120
Cell Research	TF-1 cells or primary human AML patient samples expressing mutant IDH1 are treated with AG-120. (Only for Reference)

Chemical Properties

Molecular Weight	582.961
Formula	C₂₈H₂₂ClF₃N₆O₃
Cas No.	1448347-49-6
Smiles	FC1=CN=CC(=C1)N([C@H](C(=O)NC1CC(F)(F)C1)C1=CC=CC=C1Cl)C(=O)[C@@H]1CCC(=O)N1C1=NC=CC(=C1)C#N
Relative Density.	1.51 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 100.00 mg/mL (171.54 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 237.00 mg/mL (406.55 mM), Sonication is recommended.

In Vivo Formulation

20% Cremophor EL: 5.50 mg/mL (9.43 mM)

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7154 mL	8.5769 mL	17.1538 mL	85.7690 mL
5 mM	0.3431 mL	1.7154 mL	3.4308 mL	17.1538 mL
10 mM	0.1715 mL	0.8577 mL	1.7154 mL	8.5769 mL
20 mM	0.0858 mL	0.4288 mL	0.8577 mL	4.2885 mL
50 mM	0.0343 mL	0.1715 mL	0.3431 mL	1.7154 mL
100 mM	0.0172 mL	0.0858 mL	0.1715 mL	0.8577 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.