LBH589 (Panobinostat) [404950-80-7]

Biological Activity

LBH589 (Panobinostat, NVP-LBH589) is a novel deacetylase inhibitor and has been shown to induce acetylation of histone H3 and H4, increase p21 levels, disrupt the chaperone function of hsp90, and induce cell-cycle G1 phase accumulation and apoptosis of K562 cells and acute leukemia MV4-11 cells. LBH589 (Panobinostat, NVP-LBH589) has also recently been found to significantly increase in vitro the survival of motor neuron (SMN) protein levels in cells of patients suffering from spinal muscular atrophy.

Product Citations

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  Cell Death Differ. 2026 Jan 31; .

  Targeting the USP7-PRMT6 epigenetic axis overcomes chemoresistance in breast cancer by coordinating H3R2me2a deposition and RNF168 methylation for DNA
  LBH589 (Panobinostat) purchased from AbMole

• 

  Biochem Pharmacol. 2024 Feb 17;116065.

  Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax
  LBH589 (Panobinostat) purchased from AbMole

• 

  J Biol Chem. 2022 Sep;298(9):102314.

  Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia
  LBH589 (Panobinostat) purchased from AbMole

• 

  BMC Biol. 2021 May 20;19(1):108.

  Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
  LBH589 (Panobinostat) purchased from AbMole

Customer Product Validations & Biological Datas

	Source	PLoS One (2015). Figure 2. LBH589
	Method	Apoptosis assay
	Cell Lines	SK-NEP-1 and G401 cells
	Concentrations	50 nM
	Incubation Time	24 h
	Results	The result showed that among cells treated with LBH589 50nM and 100nM for 24 hours, many more cells showed apoptotic feature compared with control group, for both SK-NEP-1 and G401 cells

Chemical Information

Molecular Weight	349.43
Formula	C21H23N3O2
CAS Number	404950-80-7
Solubility (25°C)	DMSO 59 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Thakur et al. PLoS One. ING1 and 5-Azacytidine Act Synergistically to Block Breast Cancer Cell Growth.

[2] Vallo et al. Invest New Drugs. The prostate cancer blocking potential of the histone deacetylase inhibitor LBH589 is not enhanced by the multi receptor tyrosine kinase inhibitor TKI258.

[3] Wang et al. Biol Blood Marrow Transplant. LBH589 Enhances T Cell Activation In Vivo and Accelerates Graft-versus-Host Disease in Mice.

[4] Mehdi et al. Pancreatology. HDAC gene expression in pancreatic tumor cell lines following treatment with the HDAC inhibitors panobinostat (LBH589) and trichostatine (TSA).