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Monoolein [111-03-5]

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Katalog-Nummer NB-64-29165-200mg

Size : 200mg

Marke : Neo Biotech

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Monoolein

(Synonyms: 1-Oleoyl-rac-glycerol) Copy Product Info

Synonyms: 1-Oleoyl-rac-glycerol

Catalog No. T4943 Copy Product Info

Purity: 99.12%

Monoolein (1-Oleoyl-rac-glycerol) is a surfactant that releases free glycerol and oleic acid upon hydrolysis. Monoolein has been used in liquid crystal studies and research shows that in the presence of monoolein, the penetration of the drug cisplatin (sc-200896) is doubled.

Cas No. 111-03-5

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.12%

Color:White

Product Introduction

Monoolein AI Summary

Monoolein exhibits bioactivities including inhibition of the enzyme cyclooxygenase-2 (COX2) with an inhibition rate of 24.7% at a concentration of 50 µM, and inhibition of the enzyme secretory phospholipase A2-2A (sPLA2-2A) with an inhibition rate of 60.6% at a concentration of 10 µM, as measured by a coupled enzyme assay. Additionally, Monoolein inhibits DGKalpha in human erythrocytes by interacting with OAG as a substrate, with a Ki value of 91000 nM following preincubation and the addition of OAG and [gamma-32P]ATP..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Monoolein (1-Oleoyl-rac-glycerol) is a surfactant that releases free glycerol and oleic acid upon hydrolysis. Monoolein has been used in liquid crystal studies and research shows that in the presence of monoolein, the penetration of the drug cisplatin (sc-200896) is doubled.
Synonyms	1-Oleoyl-rac-glycerol

Chemical Properties

Molecular Weight	356.54
Formula	C₂₁H₄₀O₄
Cas No.	111-03-5
Smiles	CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO
Relative Density.	0.9407 g/cm3 at 35℃

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 115 mg/mL (322.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 10 mg/mL (28.05 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8047 mL	14.0237 mL	28.0473 mL	140.2367 mL
5 mM	0.5609 mL	2.8047 mL	5.6095 mL	28.0473 mL
10 mM	0.2805 mL	1.4024 mL	2.8047 mL	14.0237 mL
20 mM	0.1402 mL	0.7012 mL	1.4024 mL	7.0118 mL
50 mM	0.0561 mL	0.2805 mL	0.5609 mL	2.8047 mL
100 mM	0.0280 mL	0.1402 mL	0.2805 mL	1.4024 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

MonooleinInhibitorinhibitEndogenousMetaboliteEndogenous Metabolite

Related Tags: Monoolein chemical structure | Monoolein formula | Monoolein molecular weight