Mouse Granzyme B (GZMB) Antibody Pair Kit (with Standard)

Katalog-Nummer MBS2099181-5x96

Size : 5x96Tests

Marke : MyBiosource


Granzyme B (GZMB) Antibody Pair Kit for Mouse

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2099181
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MBS2099181 is an antibody pair kit targeting GZMB. Also known as Mouse Granzyme B (GZMB) Antibody Pair Kit (with Standard). Reactive in Mouse. More details

Product Overview

Product Name
Granzyme B (GZMB), Antibody Pair Kit
Full Product Name
Mouse Granzyme B (GZMB) Antibody Pair Kit (with Standard)
Product Gene Name
GZMB antibody pair kit
Product Synonym Names
GZM-B; HLP; CTLA1; CCPI; CGL1; CSP-B; CSPB; CTSGL1; SECT; Granzyme 2; Cytotoxic T-Lymphocyte-Associated Serine Esterase 1; Fragmentin 2; Cytotoxic Serine Protease B
Species Reactivity
Mouse
Samples
Serum, Plasma, Tissue Homogenates and Other Biological Fluids
Detection Range
31.24-2000pg/mL
Molecular Weight
27,716 Da
OMIM
M17016 mRNA
3D Structure
ModBase 3D Structure for P10144
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Standard
Recombinant GZMB (Lyophilized, 1 vial-10ug)
Capture Antibody
Rabbit polyclonal antibody (Liquid, 1 vial-400mug/800muL)
Detection Antibody
Biotinylated Rabbit polyclonal antibody (Liquid, 1 vial-100mug/500muL)
Producte Usage
Raw materials can be used for preparation of 5x96T or 10x96T ELISA Kits.
Antibody Support Pack
Antibody Support Pack (Buffer Pack) is sold separately as catalog #MBS2090685

Product Categories/Family for GZMB antibody pair kit

ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for GZMB antibody pair kit
ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex

Other Notes

Small volumes of GZMB antibody pair kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GZMB. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
granzyme B isoform 1 preproprotein
NCBI Official Synonym Full Names
granzyme B
NCBI Official Symbol
GZMB
NCBI Official Synonym Symbols
C11; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1
UniProt Protein Name
Granzyme B
UniProt Synonym Protein Names
C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E
Protein Family
Granzyme
UniProt Gene Name
GZMB
UniProt Synonym Gene Names
CGL1; CSPB; CTLA1; GRB; CTSGL1; Lymphocyte protease; HLP
NCBI Protein Information
granzyme B

NCBI Summary for GZMB

This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
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UniProt Comments for GZMB

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GZMB antibody pair kit

 Reference Product  PubMed Publications
 PRF1 antibody pair kit  >526 publications with GZMB and PRF1
 CASP3 antibody pair kit  >87 publications with GZMB and CASP3
 BID antibody pair kit  >41 publications with GZMB and BID
 SERPINB9 antibody pair kit  >36 publications with GZMB and SERPINB9
 CASP7 antibody pair kit  >13 publications with GZMB and CASP7
 IL2RA antibody pair kit  >9 publications with GZMB and IL2RA
 IL2RB antibody pair kit  >5 publications with GZMB and IL2RB
 IL2 antibody pair kit  >2 publications with GZMB and IL2

Pathways associated with GZMB antibody pair kit

 Products by Pathway  Pathway Diagram
 Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway antibodies  Activation, Myristolyation Of BID And Translocation To Mitochondria Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram

Diseases associated with GZMB antibody pair kit

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >227 publications with GZMB and Neoplasms
 Necrosis Antibodies  >122 publications with GZMB and Necrosis
 Inflammation Antibodies  >51 publications with GZMB and Inflammation
 Neoplasms, Experimental Antibodies  >35 publications with GZMB and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >35 publications with GZMB and Disease Models, Animal
 Nervous System Diseases Antibodies  >31 publications with GZMB and Nervous System Diseases
 Liver Diseases Antibodies  >29 publications with GZMB and Liver Diseases
 Hypersensitivity Antibodies  >24 publications with GZMB and Hypersensitivity
 Breast Neoplasms Antibodies  >16 publications with GZMB and Breast Neoplasms
 Hepatitis Antibodies  >15 publications with GZMB and Hepatitis

Organs/Tissues associated with GZMB antibody pair kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >838 publications with GZMB and Blood
 Kidney Antibodies  >82 publications with GZMB and Kidney
 Lung Antibodies  >67 publications with GZMB and Lung
 Liver Antibodies  >65 publications with GZMB and Liver
 Spleen Antibodies  >63 publications with GZMB and Spleen
 Bone Marrow Antibodies  >48 publications with GZMB and Bone Marrow
 Heart Antibodies  >35 publications with GZMB and Heart
 Intestine Antibodies  >28 publications with GZMB and Intestine
 Pancreas Antibodies  >14 publications with GZMB and Pancreas
 Stomach Antibodies  >10 publications with GZMB and Stomach