Mouse Monoclonal Anti-MUC1 / EMA / CD227 (Epithelial Marker) [Clone MUC1/845]
Katalog-Nummer NB-36-00525-P1ABX
Size : 100ug
Marke : Neo Biotech
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MUC1 / CA15-3 / EMA / CD227 (Epithelial Marker) Antibody [MUC1/845]
Applications & Dilutions
Summary
In Western blotting, it recognizes proteins in MW range of 265-400kDa, identified as different glycoforms of EMA. The alpha subunit has cell adhesive properties. It can act both as an adhesion and an anti-adhesion protein. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain, which is involved in cell signaling, through phosphorylations and protein-protein interactions.In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Product Properties & Targets
Functions
- The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
- The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.
Key References
- Rughetti, A., et al. 2005. Recombinant tumor-associated Mucin 1 glycoprotein impairs the differentiation and function of dendritic cells. J. Immunol. 174: 7764-7772.
PubMed Links
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