Mouse tPA genetically deficient plasma, sodium citrate
Katalog-Nummer MBS136151-0,05mL
Size : 0.05mL
Marke : MyBiosource
PLAT Plasma – Tpa Genetically Deficient Plasma
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS136151This plasma is an ideal negative control for ELISA based assays and other experiments involving Tissue Plasminogen Activator (tPA). Collected from homozygous tPA knockout mice, anticoagulated with sodium citrate and flash frozen. Pooled from male and female… More details
Product Overview
Online Datasheet in PDFProduct Name
tPA genetically deficient plasma (PLAT), Plasma
Full Product Name
Mouse tPA genetically deficient plasma, sodium citrate
Product Gene Name
PLAT plasma
Host
tPA knockout mouse
Form/Format
Frozen liquid
Purity/Purification
Plasma
Preparation and Storage
Store at -70 degree C
Expiration: 3 years from delivery
Shipping: Dry Ice
Expiration: 3 years from delivery
Shipping: Dry Ice
Other Notes
Small volumes of PLAT plasma vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for PLAT purchase
MBS136151 is a plasma targeting PLAT. Also known as Mouse tPA genetically deficient plasma, sodium citrate. Host: tPA knockout mouse.
Additional Details
NCBI/Uniprot data below describe general gene information for PLAT. It may not necessarily be applicable to this product.
NCBI Official Full Name
tissue-type plasminogen activator preproprotein
NCBI Official Synonym Full Names
plasminogen activator, tissue
NCBI Official Symbol
Plat
NCBI Official Synonym Symbols
tPA; AU020998; AW212668; D8Ertd2e
UniProt Protein Name
Tissue-type plasminogen activator
Protein Family
Tissue-type plasminogen activator
UniProt Gene Name
Plat
UniProt Synonym Gene Names
t-PA; t-plasminogen activator; tPA
UniProt Entry Name
TPA_MOUSE
NCBI Protein Information
tissue-type plasminogen activator
NCBI Summary for PLAT
This gene encodes a key enzyme of the fibrinolytic pathway. The encoded protein undergoes proteolytic processing by plasmin to generate a heterodimeric serine protease that cleaves the proenzyme plasminogen to produce plasmin, a protease that is required to break down fibrin clots. Additionally, the encoded protein is involved in other biological processes such as synaptic plasticity, cell migration and tissue remodeling. Mice lacking the encoded protein display a reduction in long-term potentiation in hippocampus and conversely, transgenic mice overexpressing the encoded protein have increased and prolonged long-term potentiation. [provided by RefSeq, Jul 2015]
Show more UniProt Comments for PLAT
PLAT: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration. Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism. Belongs to the peptidase S1 family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Protease; EC 3.4.21.68; Secreted; Vesicle; Cytoskeletal
Cellular Component: extracellular space; cell surface; apical part of cell; cytoplasm; extracellular region; synapse; secretory granule
Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity
Biological Process: negative regulation of proteolysis; synaptic transmission, glutamatergic; smooth muscle cell migration; response to hypoxia; platelet-derived growth factor receptor signaling pathway; proteolysis; plasminogen activation
Show more Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Protease; EC 3.4.21.68; Secreted; Vesicle; Cytoskeletal
Cellular Component: extracellular space; cell surface; apical part of cell; cytoplasm; extracellular region; synapse; secretory granule
Molecular Function: peptidase activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity
Biological Process: negative regulation of proteolysis; synaptic transmission, glutamatergic; smooth muscle cell migration; response to hypoxia; platelet-derived growth factor receptor signaling pathway; proteolysis; plasminogen activation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with PLAT plasma
| Products by Pathway | Pathway Diagram |
|---|---|
| Blood Clotting Cascade Pathway antibodies | Blood Clotting Cascade Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Complement And Coagulation Cascades Pathway antibodies | Complement And Coagulation Cascades Pathway Diagram |
| Dissolution Of Fibrin Clot Pathway antibodies | Dissolution Of Fibrin Clot Pathway Diagram |
| Endochondral Ossification Pathway antibodies | Endochondral Ossification Pathway Diagram |
| Hemostasis Pathway antibodies | Hemostasis Pathway Diagram |
| Senescence And Autophagy Pathway antibodies | Senescence And Autophagy Pathway Diagram |
| Signal Transduction Pathway antibodies | Signal Transduction Pathway Diagram |
| Signaling By PDGF Pathway antibodies | Signaling By PDGF Pathway Diagram |
Diseases associated with PLAT plasma
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >25 publications with PLAT and Inflammation |
| Arterial Occlusive Diseases Antibodies | >22 publications with PLAT and Arterial Occlusive Diseases |
| Thrombosis Antibodies | >18 publications with PLAT and Thrombosis |
| Atherosclerosis Antibodies | >18 publications with PLAT and Atherosclerosis |
| Cerebral Infarction Antibodies | >13 publications with PLAT and Cerebral Infarction |
| Necrosis Antibodies | >13 publications with PLAT and Necrosis |
| Stroke Antibodies | >12 publications with PLAT and Stroke |
| Myocardial Infarction Antibodies | >12 publications with PLAT and Myocardial Infarction |
| Kidney Diseases Antibodies | >9 publications with PLAT and Kidney Diseases |
| Embolism and Thrombosis Antibodies | >9 publications with PLAT and Embolism and Thrombosis |
Organs/Tissues associated with PLAT plasma
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >36 publications with PLAT and Brain |
| Heart Antibodies | >35 publications with PLAT and Heart |
| Lung Antibodies | >28 publications with PLAT and Lung |
| Muscle Antibodies | >24 publications with PLAT and Muscle |
| Intestine Antibodies | >17 publications with PLAT and Intestine |
| Bone Antibodies | >16 publications with PLAT and Bone |
| Embryonic Tissue Antibodies | >15 publications with PLAT and Embryonic Tissue |
| Kidney Antibodies | >14 publications with PLAT and Kidney |
| Bone Marrow Antibodies | >9 publications with PLAT and Bone Marrow |
| Eye Antibodies | >9 publications with PLAT and Eye |