Orb1307017-5mg | N-Glycolylneuraminic acid [1113-83-3] Clinisciences

N-Glycolylneuraminic acid

SKU: orb1307017

Description

N-Glycolylneuraminic acid (GcNeu) is a sialic acid variant primarily found in non-human species like pigs, where it serves as a receptor for influenza A viruses (IAVs). This molecule is a key research tool for studying viral tropism, host-pathogen interactions, and zoonotic potential in both in vitro binding assays and in vivo infection models.

Research Area

Infectious Disease & Virology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	1113-83-3
MW	325.27
Purity	≥98% (May vary between batches)
Formula	C₁₁H₁₉NO₁₀
SMILES	OC[C@@H](O)[C@@H](O)[C@@H]1O[C@@](O)(C[C@H](O)[C@H]1NC(=O)CO)C(O)=O
Target	Endogenous Metabolite,Influenza Virus
Solubility	DMSO:76 mg/mL (233.65 mM)

Bioactivity

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In Vitro	Expression of N-Glycolylneuraminic acid on human cells clearly suppressed infectivity of IAVs that possess N-Glycolylneuraminic acid binding ability. Furthermore, there was no difference in infectivity of a transfectant virus that included the wild-type HA gene from A/Memphis/1/1971 (H3N2), which shows no N-Glycolylneuraminic acid binding, between parent MCF7 cells and cells stably expressing the monkey CMAH gene (CMAH-MCF7 cells). On the other hand, cell entry of the transfectant virus that included the N-Glycolylneuraminic acid-binding HA gene with a single mutation to Tyr at position Thr155 was arrested at the stage of internalization from the plasma membrane of the CMAH-MCF7 cells.

In Vitro

Expression of N-Glycolylneuraminic acid on human cells clearly suppressed infectivity of IAVs that possess N-Glycolylneuraminic acid binding ability. Furthermore, there was no difference in infectivity of a transfectant virus that included the wild-type HA gene from A/Memphis/1/1971 (H3N2), which shows no N-Glycolylneuraminic acid binding, between parent MCF7 cells and cells stably expressing the monkey CMAH gene (CMAH-MCF7 cells). On the other hand, cell entry of the transfectant virus that included the N-Glycolylneuraminic acid-binding HA gene with a single mutation to Tyr at position Thr155 was arrested at the stage of internalization from the plasma membrane of the CMAH-MCF7 cells.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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GcNeu, EndogenousMetabolite, Endogenous Metabolite, Influenza A, Influenza Virus, InfluenzaVirus, N Glycolylneuraminic acid, inhibit, Inhibitor, NeuGc, NGlycolylneuraminic acid, N-Glycolylneuraminic acid

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