NK1.1 antibody [PK136] (APC)
Cat. No. GTX01478-07
Cat. No. GTX01478-07
![Anti-NK1.1 antibody [PK136] (APC) used in Flow cytometry (FCM). GTX01478-07](/proxy_img/aHR0cDovL3d3dy5nZW5ldGV4LmNvbS91cGxvYWQvd2Vic2l0ZS9wcm91Y3RfaW1nL21pZGRsZS9HVFgwMTQ3OC0wNy9HVFgwMTQ3OC0wN18yMDIwMDQyOF9GQUNTMzFfd18yMzA1MzEyMV83ODYud2VicA==.webp)
GTX01478-07 FCM Image
FACS analysis of mouse C57Bl/6 splenocytes using GTX01478-07 NK1.1 antibody [PK136] (APC).
Right panel : co-stained with NK1.1 antibody [PK136] (APC) and Mouse CD3e antibody (FITC)
Left panel : co-stained with isotype control and Mouse CD3e antibody (FITC)
antibody amount : 0.125 μg (5 μl)
This NK1.1 antibody [PK136] (APC) (GTX01478-07) is a mouse monoclonal antibody validated for detection of NK1.1 by FCM. Reactive to mouse samples.
Summary
The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1. The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB.