Size : 100mg
Synonyms:
| Description | Nonsteroidal aromatase inhibitor 1 (Compound 13h) effectively inhibits the enzyme CYP19A1 with an IC50 value of 0.09 nM. This potent inhibitory activity suggests its potential for breast cancer research [1]. |
| In vitro | Treatment with nonsteroidal aromatase inhibitor 1 at concentrations ranging from 0.001 pM to 100 pM for 1 hour demonstrated significant aromatase inhibition, with an IC50 value of 0.09 nM, indicating excellent efficacy in inhibiting aromatase activity. Furthermore, at a concentration of 1 μM over 48 hours, the same treatment showed no significant effect on the growth of MCF-10A or MDA-MB-231 cells, implying minimal toxicity to normal breast tissue and limited off-target effects. This assessment was supported by both cell viability and cytotoxicity assays conducted on JEG-3, MCF-10A, and MDA-MB-231 cell lines. |
| Molecular Weight | 368.39 |
| Formula | C22H16N4O2 |
| Smiles | #N/A |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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