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Ostarine [841205-47-8]

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Katalog-Nummer NB-64-13346-50mg

Size : 50mg

Marke : Neo Biotech

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Ostarine

(Synonyms: MK-2866, GTX-024, Enobosarm) Copy Product Info

Synonyms: MK-2866, GTX-024, Enobosarm

Catalog No. T2408 Copy Product Info

Purity: 99.90%

Ostarine (MK-2866) is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone's action, this agent may increase lean body mass, thereby ameliorating muscle wasting in the hypermetabolic state of cancer cachexia.

Cas No. 841205-47-8

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.90%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	Ostarine (MK-2866) is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone's action, this agent may increase lean body mass, thereby ameliorating muscle wasting in the hypermetabolic state of cancer cachexia.
Targets & IC50	Androgen receptor:3.8 nM(Ki)
In vitro	Compared to any non-steroidal androgen receptor (AR) agonists, Ostarine exhibits the highest androgenic and anabolic activity in the body, particularly affecting the prostate, seminal vesicles, and levator ani muscle, with ED50 values of 0.12, 0.39, and 0.03 mg/day, respectively. This makes it four times more effective on the levator ani muscle than testosterone propionate. At a low dose of 0.03 mg/day, Ostarine demonstrates effective and selective activity in anabolic tissues. Following a single intravenous injection of 10 mg/kg, Ostarine presents a slow decline in plasma concentration with a longer half-life of 6 hours, compared to the 2.6-4.0 hours half-life when targeting other cyan/nitro substituted Selective Androgen Receptor Modulators (SARMs). In castrated male rats, Ostarine shows significant androgenic and anabolic activity, more effectively stimulating growth in the prostate, seminal vesicles, and levator ani muscle than other cyan/nitro substituted SARMs. Ostarine facilitated recovery of prostate weight by 39.2%, seminal vesicle weight by 78.8%, and notably stimulated levator ani muscle growth beyond other male organs to 141.9%.
In vivo	Ostarine (10 nM) modulates the transcriptional activity of the androgen receptor (AR) in CV-1 cells co-transfected with human androgen receptor expression vectors, luciferase reporter vectors, and β-galactosidase control vectors. Ostarine binds to the androgen receptor with the highest affinity among selective androgen receptor modulators (SARMs), exhibiting a Ki value of 3.8 nM.
Synonyms	MK-2866, GTX-024, Enobosarm

Chemical Properties

Molecular Weight	389.33
Formula	C₁₉H₁₄F₃N₃O₃
Cas No.	841205-47-8
Smiles	C[C@@](O)(COc1ccc(cc1)C#N)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 72 mg/mL (184.93 mM), Sonication is recommended.

DMSO: 250 mg/mL (642.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5685 mL	12.8426 mL	25.6852 mL	128.4258 mL
5 mM	0.5137 mL	2.5685 mL	5.1370 mL	25.6852 mL
10 mM	0.2569 mL	1.2843 mL	2.5685 mL	12.8426 mL
20 mM	0.1284 mL	0.6421 mL	1.2843 mL	6.4213 mL
50 mM	0.0514 mL	0.2569 mL	0.5137 mL	2.5685 mL
100 mM	0.0257 mL	0.1284 mL	0.2569 mL	1.2843 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

OstarineMK2866MK 2866GTX024GTX 024AndrogenReceptorAndrogen Receptor

Related Tags: Ostarine chemical structure | Ostarine in vivo | Ostarine in vitro | Ostarine formula | Ostarine molecular weight