Pertussis Toxin is a protein-based AB₅-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. Pertussis Toxin inhibits G protein-coupled receptor (GPR) signaling through Gi proteins^[1][2][3].

Pertussis toxin is a secreted protein exotoxin and an important virulence factor produced exclusively by B. pertussis^[1].
Pertussis toxin (PTX; 100 ng/ml; 12 h) completely suppresses the increase in G protein-coupled receptor kinase 2 (GRK2)-dependent migration in HeLa cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

• [1]. Carbonetti NH, et al. Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools. Future Microbiol. 2010 Mar;5(3):455-69.  [Content Brief]

  [2]. Petronila Penela, et al. G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J. 2008 Apr 23;27(8):1206-18.  [Content Brief]

  [3]. Nicholas H Carbonetti, et al. Contribution of pertussis toxin to the pathogenesis of pertussis disease. Pathog Dis. 2015 Nov;73(8):ftv073.  [Content Brief]