Pertussis Toxin (islet-activating protein)
Catalog Number: B2017280 (50 µg)
Pertussis Toxin is a protein that interferes with cellular signaling by ADP-ribosylating G proteins, impacting various cellular processes. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.
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Product Description
Pertussis Toxin (islet-activating protein)
Catalog number: B2017280
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 50 µg
Molecular Weight or Concentration: N/A
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: 2-8°C
Keywords: N/A
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
References:
1: Locht C, Antoine R. The History of Pertussis Toxin Toxins (Basel). 2021 Sep 5;13(9):623.
2: Keen AC, Pedersen MH, Lemel L, Scott DJ, Canals M, Littler DR, Beddoe T, Ono Y, Shi L, Inoue A, Javitch JA, Lane JR. OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα(z) Commun Biol. 2022 Mar 23;5(1):256.
3: Ernst K. Novel Strategies to Inhibit Pertussis Toxin Toxins (Basel). 2022 Mar 3;14(3):187.
4: Katada T. The inhibitory G protein G(i) identified as pertussis toxin-catalyzed ADP-ribosylation Biol Pharm Bull. 2012;35(12):2103-11.
5: Scanlon K, Skerry C, Carbonetti N. Association of Pertussis Toxin with Severe Pertussis Disease Toxins (Basel). 2019 Jun 27;11(7):373.
6: Gregg KA, Merkel TJ. Pertussis Toxin: A Key Component in Pertussis Vaccines? Toxins (Basel). 2019 Sep 21;11(10):557.
7: Burns DL. Secretion of Pertussis Toxin from Bordetella pertussis Toxins (Basel). 2021 Aug 18;13(8):574.
8: Mangmool S, Kurose H. G(i/o) protein-dependent and -independent actions of Pertussis Toxin (PTX) Toxins (Basel). 2011 Jul;3(7):884-99.
9: Carbonetti NH. Contribution of pertussis toxin to the pathogenesis of pertussis disease Pathog Dis. 2015 Nov;73(8):ftv073.
10: Heyworth CM, Grey AM, Wilson SR, Hanski E, Houslay MD. The action of islet activating protein (pertussis toxin) on insulin’s ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes Biochem J. 1986 Apr 1;235(1):145-9.
Products Related to Pertussis Toxin (islet-activating protein) can be found at Proteins
Additional Information
| Weight | 0.15 oz |
|---|---|
| Dimensions | 2 × 0.5 × 0.5 in |