New Delhi Metallo-β-Lactamase-1 (NDM-1) is an enzyme produced by certain bacterial strains, conferring resistance to a broad spectrum of β-lactam antibiotics, including carbapenems, which are often considered antibiotics of last resort. NDM-1's ability to hydrolyze these antibiotics poses significant challenges in treating bacterial infections, leading to limited therapeutic options and increased mortality rates. The gene encoding NDM-1 is often located on plasmids, facilitating its rapid dissemination among various bacterial species and contributing to the global spread of multidrug-resistant pathogens.

Reference: https://pubmed.ncbi.nlm.nih.gov/30700432/