STAT3 pTyr705 (703-714) Mouse Monoclonal Antibody [Clone ID: PS3/1]
CAT#: AM26475AF-N
STAT3 pTyr705 (703-714) mouse monoclonal antibody, clone PS3/1, Azide Free
Specifications
Product Data | |
Clone Name | PS3/1 |
Applications | WB |
Recommended Dilution | Western blot: 1 μg/ml. For details see protocol below. |
Reactivities | Human, Mouse, Zebrafish |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | 12 amino acids peptide (a.a. 703~714) which contained the phosphorylated Tyr708 of zebrafish STAT3 |
Specificity | This antibody reacts with human and mouse STAT3 phosphorylated at Tyr705, and zebrafish STAT3 phosphorylated at Tyr708. |
Formulation | PBS containing 50% glycerol, pH 7.2. No preservative is contained. State: Azide Free State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-A agarose |
Conjugation | Unconjugated |
Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Gene Name | signal transducer and activator of transcription 3 |
Database Link | |
Background | STAT (Signal Transducers and Activators of Transcription) proteins play important roles in development, cell differentiation, and cell cycle control. STAT3 is an ~85 kDa protein involved in the signaling pathways of many cytokines and growth factors, including GCSF and IL-6, where it functions as a negative regulator of transcription. STAT3 is also constitutively activated in a number of human tumors and it possesses anti-apoptotic activity and oncogenic potential. STAT3 may also regulate apoptosis by inhibiting NF?B. Activation of STAT3 by tyrosine phosphorylation results in dimerization, nuclear translocation, and DNA binding. |
Synonyms | STAT-3, Acute-phase response factor, APRF |
Note | This product was originally produced by MBL International. Protocol: SDS-PAGE & Western Blotting |
Reference Data |
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