| Short Description : | Rabbit polyclonal anti-Probable G-protein coupled receptor 179 for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC/IF |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | IHC-P 1:50-300IF 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
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| Immunogen: | Synthesized peptide derived from part of the human protein |
| Specificity: | GP179 Polyclonal Antibody detects endogenous levels of protein. |
| Function | Orphan receptor involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. Acts as an atypical G-protein coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1. |
| Protein Name | Probable G-Protein Coupled Receptor 179Probable G-Protein Coupled Receptor 158-Like 1Gpr158-Like |
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| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCell ProjectionDendriteSpecifically Localizes To The Tips Of Retinal On-Bipolar Dendrites |
| Alternative Antibody Names | Anti-Probable G-Protein Coupled Receptor 179 antibodyAnti-Probable G-Protein Coupled Receptor 158-Like 1 antibodyAnti-Gpr158-Like antibodyAnti-GPR179 antibodyAnti-GPR158L antibodyAnti-GPR158L1 antibody |
Information sourced from Uniprot.org