General Info
Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-ZP3 (246-345) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | ZP3 |
Gene ID: | 7784 |
Uniprot ID: | ZP3_HUMAN |
Immunogen Region: | 246-345 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 246-345 of human ZP3 (NP_001103824.1). |
Immunogen Sequence: | DASSAFKVPRPGPDTLQFTV DVFHFANDSRNMIYITCHLK VTLAEQDPDELNKACSFSKP SNSWFPVEGSADICQCCNKG DCGTPSHSRRQPHVMSQWSR |
Description
Tissue Specificity | Expressed in oocytes (at protein level). |
Post Translational Modifications | Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. N-glycosylated. O-glycosylated.removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy. |
Function | Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. |
Protein Name | Zona Pellucida Sperm-Binding Protein 3Sperm ReceptorZp3a/Zp3bZona Pellucida Glycoprotein 3Zp-3Zona Pellucida Protein C Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 3 |
Database Links | Reactome: R-HSA-2534343 |
Cellular Localisation | Processed Zona Pellucida Sperm-Binding Protein 3: Zona PellucidaCell MembraneSingle-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Zona Pellucida Sperm-Binding Protein 3 antibodyAnti-Sperm Receptor antibodyAnti-Zp3a/Zp3b antibodyAnti-Zona Pellucida Glycoprotein 3 antibodyAnti-Zp-3 antibodyAnti-Zona Pellucida Protein C Cleaved Into - Processed Zona Pellucida Sperm-Binding Protein 3 antibodyAnti-ZP3 antibodyAnti-ZP3A antibodyAnti-ZP3B antibodyAnti-ZPC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance