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Astaxanthin [472-61-7]

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Katalog-Nummer NB-64-20007-5mg

Size : 5mg

Marke : Neo Biotech

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Astaxanthin

(Synonyms: β-Carotene-4,4'-dione, trans-Astaxanthin, Ovoester, AstaREAL) Copy Product Info

Synonyms: β-Carotene-4,4'-dione, trans-Astaxanthin, Ovoester, AstaREAL

Catalog No. T3138 Copy Product Info

Purity: 99.79%

Astaxanthin (trans-Astaxanthin) is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activity. It is present in most red-colored aquatic organisms. Astaxanthin has shown to mediate anti-oxidant and anti-inflammatory actions. It may be found in fish feed or some animal food as a color additive.

Cas No. 472-61-7

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.79%

Color:Purple to Black

Product Information

Astaxanthin AI Summary

Astaxanthin exhibits diverse pharmacological activities including antiradical, antiplasmodial, hypoglycemic, antidiabetic, antiviral, and inhibitory effects on specific proteins. It acts as a DPPH radical scavenger with a 52.0% activity at a concentration of 1500 µM. It shows antiplasmodial activity against Plasmodium falciparum strains W2, 7G8, and GB4 with IC50 values of 7943.28 nM for the W2 and 7G8 strains, and 12589.25 nM for the GB4 strain. In mouse models, at a dosage of 10 mg/kg, it reduces plasma glucose levels, demonstrating hypoglycemic activity by lowering glucose levels by 6.02 mmol/L and 6.14 mmol/L in oral glucose tolerance tests, and antidiabetic activity by reducing glucose levels by 10.11 mmol/L and 13.03 mmol/L in an alloxan-induced diabetic model. Astaxanthin inhibits the activity of OATP1B1 and OATP1B3 in CHO cells with inhibition rates of 95.25% and 87.19% respectively at 10 µM. It also shows antiviral activity by reducing SARS-CoV-2 induced cytotoxicity in Caco-2 cells by approximately 29.9% at a concentration of 10 µM after 48 hours and slightly inhibits SARS-CoV-2 3CL-Pro protease by 17.74% at a concentration of 20 µM. Furthermore, it inhibits the cytotoxicity of SARS-CoV-2 in VERO-6 cells by 2.6% at 10 µM concentration after 48 hours and shows a 10.39% inhibitory activity against human HDAC6 with a commercial peptide substrate, although it does not inhibit with a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Astaxanthin (trans-Astaxanthin) is a keto-carotenoid in the terpenes class of chemical compounds. It is classified as a xanthophyll but it is a carotenoid with no vitamin A activity. It is present in most red-colored aquatic organisms. Astaxanthin has shown to mediate anti-oxidant and anti-inflammatory actions. It may be found in fish feed or some animal food as a color additive.
Synonyms	β-Carotene-4,4'-dione, trans-Astaxanthin, Ovoester, AstaREAL

Chemical Properties

Molecular Weight	596.84
Formula	C₄₀H₅₂O₄
Cas No.	472-61-7
Smiles	C\C(\C=C\C=C(/C)\C=C\C1=C(C)C(=O)[C@@H](O)CC1(C)C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)C(=O)[C@@H](O)CC1(C)C
Relative Density.	1.071 g/cm3

Storage & Solubility Information

Storage

Store at low temperature,Keep away from direct sunlight,Store under nitrogen,The compound is unstable in solution. Please use soon, Pure form: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.97 mg/mL (10 mM), Sonication is recommended.

DMF: 1 mg/mL (1.68 mM), Sonication is recommended.

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6755 mL	8.3775 mL	16.7549 mL	83.7745 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.3351 mL	1.6755 mL	3.3510 mL	16.7549 mL
10 mM	0.1675 mL	0.8377 mL	1.6755 mL	8.3775 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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