Size : 5g
Synonyms: Deferidone, CP20
| Description | Deferiprone (Deferidone) is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity. |
| In vitro | At a concentration of 1 mM, Deferiprone causes a significant decrease in complex I-III activity in iron-overloaded cardiomyocytes. It exhibits cytotoxic effects on human tumor cell lines HSC-2, HSC-3, and HL-60, with IC50 values of 13.5 μg/mL, 9.9 μg/mL, and 10.6 μg/mL, respectively. The cytotoxicity of HK1 against HL-60 and HSC-2 cells is reduced in the presence of FeCl3. At 100 μg/mL, Deferiprone induces inter-nucleosomal DNA fragmentation in HL-60 cells, a process inhibited by the addition of FeCl3. Protection of myocytes from doxorubicin-induced lactate dehydrogenase release is observed with 100 μM Deferiprone. It effectively inhibits the transfer of radiolabeled iron from iron-loaded cardiomyocytes and protects or restores mitochondrial respiratory enzyme activity in a xanthine oxidase/hypoxanthine superoxide generating system at a concentration of 0.3 mM. Furthermore, 0.5 mM Deferiprone enhances the clearance of free iron from RBC membranes in a time- and dose-dependent manner. A 3 mM concentration significantly reduces hydroxyl radical production from the iron(III)-adriamycin complex in the xanthine oxidase/hypoxanthine superoxide generating system. |
| In vivo | Administration of 100 mg/kg Deferiprone resulted in a 24% reduction in the average cross-sectional area of the basilar artery in rabbits. When combined with subarachnoid hemorrhage (SAH), Deferiprone also demonstrated variability in the waviness of the internal elastic lamina in rabbits. |
| Synonyms | Deferidone, CP20 |
| Molecular Weight | 139.15 |
| Formula | C7H9NO2 |
| Cas No. | 30652-11-0 |
| Smiles | OC1=C(C)N(C)C=CC1=O |
| Relative Density. | 1.225 g/cm3 |
| Storage | Keep away from moisture Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 1.34 mg/mL (9.63 mM), Sonication is recommended.  H2O: 8.06 mg/mL (57.92 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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