GNRH1 Antibody
Katalog-Nummer CSB-PA008890-50ug
Size : 50ug
Marke : Cusabio
Product Details
Uniprot No.
Target Names
Alternative Names
GNRH1 antibody; GNRH antibody; GRH antibody; LHRHProgonadoliberin-1 antibody; Progonadoliberin I) [Cleaved into: Gonadoliberin-1 antibody; Gonadoliberin I antibody; Gonadorelin antibody; Gonadotropin-releasing hormone I antibody; GnRH-I antibody; Luliberin I antibody; Luteinizing hormone-releasing hormone I antibody; LH-RH I); GnRH-associated peptide 1 antibody; GnRH-associated peptide I)] antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human GnRH I.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
| Application | Recommended Dilution |
|---|---|
| IHC | 1:100-1:300 |
| ELISA | 1:10000 |
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Customer Reviews and Q&A
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Target Background
Function
Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Gene References into Functions
- High expression of LHRH is associated with ovarian cancer.
- GNRH (and GNRHR) are expressed in trophoblast cell populations and fallopian tube epithelium at tubal ectopic pregnancy sites.
- High LHRH expression is associated with sarcomas of bone and soft tissue.
- mutations in the region encoding the decapeptide associated with complete Idiopathic hypogonadotropic hypogonadism
- GnRH regulates trophoblast invasion via RUNX2-mediated MMP2/MMP9 expression.
- analysis of information transfer via gonadotropin-releasing hormone receptors to extracellular signal-regulated kinase or nuclear factor of activated T-cells
- our results showed that GnRH participates in the self-renewal capacity and stemness maintenance of LCSLCs by upregulating the JNK signaling pathway, and GnRH may be useful as an alternative lung cancer stem-like cells therapy.
- Melatonin affects the secretion of GnRH, LH and testosterone, improves sperm quality thereby regulating the testicular development and male reproduction. (Review)
- Data suggest differences in regulation of expression of PEDF (up-regulation) vs. VEGF (down-regulation) in granulosa cells explain reduced risk of ovarian hyperstimulation syndrome due to ovulation induction using GnRH/GNRHR agonists rather than hCG.
- No abnormalities were found in the patient group for the PROKR2 and GNRH1genes. In addition, no genomic rearrangements were identified in the healthy control individuals for the described genes
- Haploinsufficiency of Dmxl2, encoding a synaptic protein, causes infertility associated with a loss of GnRH neurons in humans and mice.
- Data indicate that the gene expression pattern is profoundly different between human chorionic gonadotropin (hCG) and gonadotropin-releasing hormone (GnRH) agonist.
- GnRH agonists fail to increase Bax expression and do not potentiate the cytotoxic activity of docetaxel
- GnRH, through heterotopic expression of its receptor, may be a potential regulator of CYP11B2 expression levels in some cases