Methyl-β-cyclodextrin [128446-36-6]
Katalog-Nummer HY-101461-500mg
Size : 500mg
Marke : MedChemExpress
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis. Methyl-β-cyclodextrin blocks cell migrasome formation.
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Methyl-β-cyclodextrin Chemische Struktur
CAS. Nr. : 128446-36-6
This product is a controlled substance and not for sale in your territory.
Based on 44 publication(s) in Google Scholar
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Methyl-β-cyclodextrin purchased from MedChemExpress. Usage Cited in: J Med Virol. 2022 Nov 1. [Abstract]
- Pretreatment with AY9944 (15, 30 µM), U18666A (5, 10 µM), lovastatin (5, 10 µM) and Methyl-β-cyclodextrin (MβCD; 5, 10 mM) for 2 h can all significantly reduce the level of EV-A71 VP1 protein in HCT-8 cell.
Beschreibung |
Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a cyclic heptasaccharide used to deliver hydrophobic agents based on its property of solubilizing non-polar substances. Methyl-β-cyclodextrin is also extensively used as a cholesterol-depleting reagent[1]. Methyl-β-cyclodextrin strongly reduces clathrin-dependent endocytosis[2]. Methyl-β-cyclodextrin blocks cell migrasome formation[3]. |
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In Vitro |
Methyl-β-cyclodextrin is extensively used to increase the permeability of cells, and thereby increase the uptake of small molecules such as glucose and nano-particles[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
In a PEL xenograft mouse model, Methyl-β-cyclodextrin significantly inhibits the growth and invasion of PEL cells without apparent adverse effects. Methyl-β-cyclodextrin-treated mice appears to be healthy, whereas non-treated mice has a distended abdominal region. The body weights of control are significantly higher than those of Methyl-β-cyclodextrin treated mice. Methyl-β-cyclodextrin-treated mice has a significantly lower volume of ascites than that of non-treated mice[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molekulargewicht |
1310 (Average) |
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CAS. Nr. |
128446-36-6 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
CO[C@@H]1[C@H](O[R])[C@H](O[R])[C@@H](C)C(CO[R])O1.[7].[R=H or -CH3] |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : ≥ 100 mg/mL H2O : ≥ 50 mg/mL *"≥" means soluble, but saturation unknown.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Reinheit & Dokumentation |
Purity: 99.95% |
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Verweise |
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Methyl-β-cyclodextrin Related Classifications
- Others
- Biochemical Assay Reagents