Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie

Pioglitazone [111025-46-8]

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Katalog-Nummer T0214-50mg

Size : 50mg

Marke : TargetMol

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Pioglitazone

(Synonyms: U 72107) Copy Product Info

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Pioglitazone (U 72107) is a PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively, and has selective and oral activity. Pioglitazone can be used in diabetes research.

Cas No. 111025-46-8

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:99.82%

Color:White

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COA HNMR LCMS

Product Information

Bioactivity

Description	Pioglitazone (U 72107) is a PPARγ agonist with EC50 of 0.93 and 0.99 μM on human and mouse PPARγ, respectively, and has selective and oral activity. Pioglitazone can be used in diabetes research.
Targets & IC50	PPARα (mouse):100 μM (EC50), PPARγ (human):0.93 μM (EC50), PPARα (human):100 μM (EC50), PPARγ (mouse):0.99 μM (EC50), PPARδ (human):43 μM (EC50)
In vitro	METHODS: HT-1080, MDA-MB-231, and PC-3 cells were treated with Pioglitazone for 3 days, and target cell toxicity was measured using MTT assay. RESULTS: Pioglitazone did not affect cell growth at 100 μM. [1]
In vivo	METHODS: To investigate the effect of Pioglitazone on insulin resistance, Pioglitazone (10 and 30 mg/kg) was orally administered to ob/ob and adipo-/-ob/ob mice once daily for 14 days. RESULTS: Pioglitazone improves insulin resistance and diabetes, which may be lipocalin-dependent in the liver but not in skeletal muscle. [2] METHODS: To investigate the effect of Pioglitazone on cardiac remodeling, diabetic nephropathy rats were treated with oral administration of Pioglitazone (10 mg/kg) once daily for 4 weeks. RESULTS: Pioglitazone significantly reduced body weight (BW), cardiac hypertrophy, elevated blood glucose levels, and related dyslipidemia. [3]
Synonyms	U 72107

Chemical Properties

Molecular Weight	356.44
Formula	C₁₉H₂₀N₂O₃S
Cas No.	111025-46-8
Smiles	C(C1C(=O)NC(=O)S1)C2=CC=C(OCCC3=CC=C(CC)C=N3)C=C2
Relative Density.	1.26 g/cm3

Storage & Solubility Information

Storage

Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 28.8 mg/mL (80.8 mM), Heating is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.61 mM), Sonication is recommended.

10% DMSO+40% PEG300+ 5% Tween 80 + 45% Saline: 2.88 mg/mL (8.08 mM), Solution.

10% DMSO+90% Saline: < 2.88 mg/mL (8.08 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8055 mL	14.0276 mL	28.0552 mL	140.2761 mL
5 mM	0.5611 mL	2.8055 mL	5.6110 mL	28.0552 mL
10 mM	0.2806 mL	1.4028 mL	2.8055 mL	14.0276 mL
20 mM	0.1403 mL	0.7014 mL	1.4028 mL	7.0138 mL
50 mM	0.0561 mL	0.2806 mL	0.5611 mL	2.8055 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.