Size : 1g
Synonyms: 2-Aminoethanesulfonic acid
| Description | Taurine (2-Aminoethanesulfonic acid) is an organic acid widely distributed in animal tissues and is one of the constituents of bile acids. Taurine is involved in a number of processes related to energy expenditure and muscle function, and can treat fatigue and muscles as well as improve immune function. |
| Targets & IC50 | HEK293 cells:10 μM (EC50), L6 cells:> 90 μg/mL, Hepatocyte cells (rat):24.23 g/L |
| In vitro | METHODS: Primary alveolar epithelial cells from mice were treated with TGF-β1 (1-3 ng/mL) and TD139 (10 µM), and the expression levels of target proteins were detected by Western Blot. RESULTS: TD139 blocked TGF-β1-induced β-catenin phosphorylation. [1] METHODS: FTC-133 and 8505C cells were treated with TD139 (0-100 µM) for 72 h. Cell viability was determined by CCK8 assay. RESULTS: TD139 decreased cell viability in a dose-dependent manner. [2] |
| In vivo | METHODS: To investigate the effect on the fibrotic phase of bleomycin-induced lung injury, TD139 (10 µg) was administered as an endotracheal drip to the lungs of mice with pulmonary fibrosis four times every two days. RESULTS: In the lungs of WT mice treated with TD139, there was a significant reduction in fibrosis and β-catenin activation, as well as a decrease in galectin-3 expression.TD139 significantly reduced the total amount of pulmonary collagen. At the same time, the fibrosis score decreased from 3.8±0.4 to 2.6±0.3. In the absence of bleomycin, TD139 had no effect on fibrosis. [1] |
| Synonyms | 2-Aminoethanesulfonic acid |
| Molecular Weight | 125.15 |
| Formula | C2H7NO3S |
| Cas No. | 107-35-7 |
| Smiles | O=S(=O)(O)CCN |
| Relative Density. | 1.494 g/cm3 |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 88.3 mg/mL (705.55 mM), Sonication is recommended.  DMSO: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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