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Reagenzien und Instrumente für die Immunologie Zellbiologie und Molekularbiologie

Tigecycline mesylate [1135871-27-0]

Drucken

Katalog-Nummer B1220-10mg

Size : 10mg

Contact local distributor :

Telefonnummer : +1 850 650 7790

Marke : ApexBio Technology

Contact local distributor :

Telefonnummer : +1 850 650 7790

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Background

Tigecycline mesylate a first-in-class, broad spectrum antibiotic with activity against antibiotic-resistant organisms.

Chemical Properties

Storage	Store at -20°C
M.Wt	681.75
Cas No.	1135871-27-0
Formula	C₃₀H₄₃N₅O₁₁S
Solubility	Soluble in DMSO
Chemical Name	(4S,4aS,5aR,12aS)-9-((Z)-(2-(tert-butylamino)-1-hydroxyethylidene)amino)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carbimidic acid compound with methanesulfonic acid (1:1)
SDF	Download SDF
Canonical SMILES	CC(C)(NC/C(O)=N/C1=CC(N(C)C)=C(C2=C1O)C[C@@](C(C2=O)=C(O)[C@@]34O)(10)C[C@@]3(10)[C@@](N(C)C)(10)C(O)=C(C(O)=N)C4=O)C.CS(O)(=O)=O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment [1]:
Cell lines	Human leukemic cell culture
Preparation method	The solubility of this compound in DMSO is soluble. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition	0.63-30 µM
Applications	The results showed that tigecycline had the ability to inhibit mitochondrial translation as it had in vitro and in vivo activity against acute myeloid leukemia (AML). Tigecycline was relatively unstable after reconstruction, and this instability might limit the use of the drug to treat infections in ambulatory infusions and prevent the development of optimal dosage regimens for AML.
Animal experiment [1]:
Animal models	NOD / SCID mice model of acute myeloid leukemia (AML) xenograft
Dosage form	50mg/kg (i.p.), twice daily for 11 days
Application	Both tigecycline and the new formulation reduced tumor volume and weight with similar efficacy.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1]. Jitkova Y, Gronda M, Hurren R, Wang X, Goard CA, Jhas B, Schimmer AD. A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity. PLoS One. 2014 May 28;9(5):e95281. doi: 10.1371/journal.pone.0095281. eCollection 2014. PubMed PMID: 24871339; PubMed Central PMCID: PMC4037176.

Quality Control

Purity = 98.00%

Chemical structure

Tigecycline mesylate