Toll-Like Receptors (TLR)
Summary of Toll-like Receptors&their Ligands
(Click on the links below for TLR antibodies)
(Click on the links below for TLR antibodies)
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Receptor |
Bacteria | Viruses | Fungi | Parasites | Small/Synthetic Molecules | Endogenous Ligands |
| TLR1 / TLR2 |
Triacyl lipopeptides lipoarabinomannan (LAM) from mycobacterium |
Yeast/ Zymosan |
Glycosylphosphatidyl inositol linked proteins, T. cruzi |
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| TLR2 / TLR2 (?) | Published literature suggests the existence of TLR2 homo-dimers, though specific ligands have yet to be identified. | |||||
| TLR2 / TLR6 |
diacyl lipopeptides, LTA peptidoglycan |
Yeast/ Zymosan |
Glycosylphosphatidyl inositol linked proteins, T. cruzi |
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| TLR3 | dsRNA | |||||
| TLR4 | LPS |
(Mouse TLR4), Taxol |
Hsp60, Hsp70?, Hyaluronic Acid? Heparan Sulfate? Fibrinogen? |
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| TLR5 | Flagellin | |||||
| TLR7 | ssRNA |
Imidazoquinolines (Mouse TLR7), Loxoribine |
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| TLR8 | ssRNA | (Human TLR8) Imidazoquinolines | ||||
| TLR9 |
Bacterial CpG |
Viral CpG | ||||
| TLR10 | Unknown ligand(s) | |||||
| TLR11 |
(Mouse TLR11) Uropathogenic Bacteria |
(Mouse TLR11) T. gondii profilin, apicomplexan profilins? |
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| TLR12 |
Unknown ligand(s) |
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| TLR13 |
Unknown ligand(s) |
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Other TLR products |
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