Aloin [1415-73-2]
Katalog-Nummer HY-N0123-1ml
Size : 10mM/1mL
Marke : MedChemExpress
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
Aloin Chemische Struktur
CAS. Nr. : 1415-73-2
This product is a controlled substance and not for sale in your territory.
Based on 7 publication(s) in Google Scholar
Other Forms of Aloin:
- Aloin B In-stock
Beschreibung |
Aloin (Aloin-A; Barbaloin-A) is a natural anti-tumor anthraquinone glycoside with iron chelating activity. Aloin induces the differentiation of MC3T3-E1 cells into osteoblasts through MAPK-mediated Wnt and Bmp signaling pathways. Alkaline phosphatase (ALP) is an early marker of osteoblast differentiation, and the activity of ALP is also enhanced by Aloin. Aloin also reduces brain edema, reduces blood-brain barrier disruption and improves cortical impact injuries. Aloin is used in research into osteoporosis and traumatic brain injury (TBI)[1][2][3][4]. |
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In Vitro |
Aloin (0.01-1 μM; 10 d) enhances the expression of osteoblast differentiation genes, Bmp-2, Runx2, and collagen 1a in a dose-dependent manner[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
Aloin (10-30 mg/kg; sinlge dose; ip 30 min before TBI injury) ameliorates traumatic brain injury (TBI) induced brain edema by controlled cortical impact injury in mice. Aloin exhibits antioxidant stress and anti-apoptotic properties in mouse brain capillary endothelial cells[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molekulargewicht |
418.39 |
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Formel |
C21H22O9 |
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CAS. Nr. |
1415-73-2 |
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Unlabeled CAS |
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Appearance |
Solid |
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Color |
Light yellow to yellow |
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SMILES |
O=C1C2=C(C=CC=C2O)[C@H]([C@]3(06)O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C4=CC(CO)=CC(O)=C14 |
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Structure Classification |
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Initial Source |
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Versand | Room temperature in continental US; may vary elsewhere. |
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Speicherung |
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Lösungsmittel & Löslichkeit |
In Vitro:
DMSO : 125 mg/mL (298.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Reinheit & Dokumentation |
Purity: 98.32% |
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Verweise |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.3901 mL | 11.9506 mL | 23.9011 mL | 59.7529 mL |
5 mM | 0.4780 mL | 2.3901 mL | 4.7802 mL | 11.9506 mL | |
10 mM | 0.2390 mL | 1.1951 mL | 2.3901 mL | 5.9753 mL | |
15 mM | 0.1593 mL | 0.7967 mL | 1.5934 mL | 3.9835 mL | |
20 mM | 0.1195 mL | 0.5975 mL | 1.1951 mL | 2.9876 mL | |
25 mM | 0.0956 mL | 0.4780 mL | 0.9560 mL | 2.3901 mL | |
30 mM | 0.0797 mL | 0.3984 mL | 0.7967 mL | 1.9918 mL | |
40 mM | 0.0598 mL | 0.2988 mL | 0.5975 mL | 1.4938 mL | |
50 mM | 0.0478 mL | 0.2390 mL | 0.4780 mL | 1.1951 mL | |
60 mM | 0.0398 mL | 0.1992 mL | 0.3984 mL | 0.9959 mL | |
80 mM | 0.0299 mL | 0.1494 mL | 0.2988 mL | 0.7469 mL | |
100 mM | 0.0239 mL | 0.1195 mL | 0.2390 mL | 0.5975 mL |